Less endurance? Harder to bounce back? Fatigue that just won’t go away?
Stop biological aging at the source by rebuilding your mitochondria with a little-known compound called Urolithin A.
the science of living better, longer
As you age, your mitochondria—the energy powerhouses of every cell—become damaged and dysfunctional.
Fatigue, reduced resilience, declining endurance, and accelerated biological aging is the result.
Urolithin A is a powerful, research-backed compound that activates mitophagy, your body’s natural process for clearing and cleaning damaged mitochondria…
…while also stimulating the creation of new, healthy mitochondria, helping restore your natural energy, strength, and cellular health.
the science of living better, longer
As you age, your mitochondria—the energy powerhouses of every cell—become damaged and dysfunctional. Fatigue, reduced resilience, declining endurance, and accelerated biological aging is the result.
Urolithin A is a powerful, research-backed compound that activates mitophagy, your body’s natural process for clearing and cleaning damaged mitochondria…
…while also stimulating the creation of new, healthy mitochondria, helping restore your natural energy, strength, and cellular health.
Warning Signs Your Cellular Renewal System Needs Support:
- Unexplained fatigue that rest doesn't fix
- Brain fog and memory issues that impact daily life
- Declining strength despite regular activity
- Slower recovery from physical or mental challenges
- Changes in body composition resistant to diet and exercise
- Reduced resilience to stress
just 1-2 capsules a day of Urolithin a can help you:
- Maintain independence and strength throughout life
- Support robust cardiovascular and metabolic health
- Preserve sharp thinking and mental clarity
- Build cellular resilience against aging
- Stay active and capable at any age
- Support whole-body vitality and function
Activate Your Body's Anti-Aging Switch:
The Science of Mitophagy
Every cell in your body relies on a critical renewal process that declines with age.
This process—mitophagy—doesn’t just clear out cellular damage.
It’s the master switch that determines how well your cells produce energy, how quickly you age, and how resilient you remain over time.
Mitophagy: The Master of Cellular Regeneration
When this process slows down, every system in your body feels it, from your brain to your muscles to your metabolism.
This isn’t typical aging—it’s losing your ability to regenerate and maintain peak function at the cellular level.
Flip the Aging Switch with Urolithin A, A Breakthrough in Mitophagy
“The natural postbiotic Urolithin A has been shown to promote mitophagy, mitochondrial function, and improved muscle function across species in different experimental models and across multiple clinical studies.”
Research reveals that Urolithin A directly signals mitophagy, reactivating this crucial renewal process that naturally declines with age.
your body needs urolithin a,
but can your gut produce it?
Nature’s most potent longevity foods—pomegranates, walnuts, berries, and chestnuts—contain a remarkable compound called ellagitannin. Through millions of years of evolution, your gut microbiome developed the unique ability to transform ellagitannin into Urolithin A.
but Most people can't produce Urolithin A... even with a perfect diet
Here’s the modern dilemma: Even when people consistently consume these ellagitannin-rich foods, most can’t produce significant amounts of Urolithin A.
your body needs urolithin a,
but can your gut produce it?
Nature’s most potent longevity foods—pomegranates, walnuts, berries, and chestnuts—contain a remarkable compound called ellagitannin.
Through millions of years of evolution, your gut microbiome developed the unique ability to transform ellagitannin into Urolithin A.
but Most people can't produce Urolithin A... even with a perfect diet
Here’s the modern dilemma: Even when people consistently consume these ellagitannin-rich foods, most can’t produce significant amounts of Urolithin A.
are your gut bugs up to the task?
A 2022 Swiss study found that only 40% of participants had a microbiome that could produce urolithin A [4]
“Not everyone has a microbiome capable of producing urolithin A, making supplementation…an appealing strategy.”
Research shows that even after regular consumption of pomegranate juice, 60% of people either produce very little Urolithin A or none at all.
Widespread factors in today’s world compromise your microbiome’s ability to produce this vital compound:
- Processed foods and low-fiber diets deplete your beneficial gut bacteria
- Frequent antibiotic use disrupts your microbiome
- Chronic stress and environmental toxins alter your gut health
- Metabolic issues and inflammation affect your gut's converting ability
- Lack of ellagitannin-rich foods like chestnuts, walnuts, pomegranates, raspberries, strawberries, and pecans in the standard diet
The solution:
Direct access to urolithin a
Science has given us a breakthrough way to deliver urolithin A directly to your cells, bypassing the need for gut conversion.
Now, there’s a simple way to benefit from this powerful, mitophagy-activating molecule to restore your energy, strength, and cellular health, regardless of your gut’s ability to produce it.
This means you can:
- Activate your body's natural mitochondrial cleanup system (mitophagy) even if you don’t have the ideal microbiome
- Get a precise, research-backed dose every time
- Support the creation of new, healthy mitochondria
- Maintain cellular energy and strength into advanced age
- Support a key hub of healthy biological aging at the cellular level: your mitochondria
Plus, a fantastic bonus!
While supporting cellular health, Urolithin A also directly benefits gut health, creating a regenerative cycle from the inside out. [7, 8]
Research-Validated: Urolithin A's Profound Impact on Human Health
Clinical studies reveal that 1-2 capsules a day of Urolithin A triggers profound changes at the cellular level, delivering benefits previously thought impossible.
Urolithin A provides you with the amounts shown in human studies to:
- Activate mitophagy, your body's critical mitochondrial cleanup system that declines with age
- Optimize immune health
- Significantly increase VO2max, one of the most powerful predictors of longevity
- Increases cellular energy production
- Dramatically improve muscle strength and endurance in young, middle-aged, and older adults by halting age-related muscle tissue breakdown
- Improve cardiovascular health
- Strengthen vascular function
- Dramatically increase HDL ("good") cholesterol
- Optimize blood sugar regulation
- Benefit multiple pathways implicated in biological aging
- Reduce levels of oxidative stress
- Decrease inflammatory markers
- Possibly protect the brain from age-related atrophy
- Amplify the loss of adipose tissue, especially belly fat
- Possibly support men with prostate cancer
- Optimize vascular function and minimize cardiometabolic risk
- Aid balanced blood sugar
- Deaccelerate biological aging and prolong healthspan
These aren’t just minor improvements – they represent fundamental changes in how your cells function, potentially altering the trajectory of your aging process.
“...The Urolithin A group exhibited superior performance enhancements in Maximum Voluntary Isometric Contraction (MVIC) and repetitions to failure (RTF) compared to the placebo group.” [11]
SIMPLE TRANSLATION OF THIS STUDY
A recent 2024 study showed that those that consumed Urolithin A showed dramatic improvement in muscle strength and endurance by halting age-related muscle tissue breakdown.
*/** Significant difference (p<0.05).
Urolithin A: where the immune system, mitochondria, and microbiome meet [21]
Urolithin A creates a therapeutic cross-talk between your immune system, mitochondria, and microbiome.
How?
It works as a diverse biochemical signaler that enhances your body’s own immune, mitochondrial, and microbial functions.
Learn more about the research on Urolithin A: [4]
- Activates the PINK1/Parkin mitochondrial quality control pathway— optimizes your energy, metabolism, and cell function
- Stimulates the Nrf2-ARE signaling pathway that leads to the production of potent internal antioxidants— defends you from brain fog, fatigue, and other signs of aging
- Supports the expression of glutathione S-transferases, phase 2 detoxification enzymes— shields your mitochondria from oxidative stress and helps you release harmful toxins
- Downregulates pro-inflammatory immune compounds such as C-reactive protein— guards against inflammation in your metabolic, cardiovascular, and musculoskeletal systems
- Positively impacts the microbiome [22] and intestinal lining [7, 8]— may increase microbial diversity and intestinal lining health and function
Just 1-2 capsules a day of urolothin a can help you:
- Maintain independence and strength throughout life
- Support robust cardiovascular and metabolic health
- Preserve sharp thinking and mental clarity
- Build cellular resilience against aging
- Stay active and capable at any age
- Support whole-body vitality and function
- Maintain independence and strength throughout life
- Support robust cardiovascular and metabolic health
- Preserve sharp thinking and mental clarity
- Build cellular resilience against aging
- Stay active and capable at any age
- Support whole-body vitality and function
Full Transparency On The Label
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References
All References
Showing all foods in which the polyphenol Ellagic acid is found – Phenol-Explorer [Internet]. [cited 2025 Jan 22]. Available from: http://phenol-explorer.eu/contents/polyphenol/417
Zhao H, Song G, Zhu H, Qian H, Pan X, Song X, et al. Pharmacological Effects of Urolithin A and Its Role in Muscle Health and Performance: Current Knowledge and Prospects. Nutrients. 2023;15:4441.
Faitg J, D’Amico D, Rinsch C, Singh A. Mitophagy Activation by Urolithin A to Target Muscle Aging. Calcified tissue international [Internet]. 2024 [cited 2025 Jan 22];114. Available from: https://pubmed.ncbi.nlm.nih.gov/37925671/
Singh A, D’Amico D, Andreux PA, Dunngalvin G, Kern T, Blanco-Bose W, et al. Direct supplementation with Urolithin A overcomes limitations of dietary exposure and gut microbiome variability in healthy adults to achieve consistent levels across the population. European journal of clinical nutrition [Internet]. 2022 [cited 2025 Jan 22];76. Available from: https://pubmed.ncbi.nlm.nih.gov/34117375/
Mora-Cubillos X, Tulipani S, Garcia-Aloy M, Bulló M, Tinahones FJ, Andres-Lacueva C. Plasma metabolomic biomarkers of mixed nuts exposure inversely correlate with severity of metabolic syndrome. Molecular nutrition & food research [Internet]. 2015 [cited 2025 Jan 22];59. Available from: https://pubmed.ncbi.nlm.nih.gov/26412215/
Puupponen-Pimiä R, Seppänen-Laakso T, Kankainen M, Maukonen J, Törrönen R, Kolehmainen M, et al. Effects of ellagitannin-rich berries on blood lipids, gut microbiota, and urolithin production in human subjects with symptoms of metabolic syndrome. Molecular nutrition & food research [Internet]. 2013 [cited 2025 Jan 22];57. Available from: https://pubmed.ncbi.nlm.nih.gov/23934737/
García-Villalba R, Vissenaekens H, Pitart J, Romo-Vaquero M, Espín JC, Grootaert C, et al. Gastrointestinal Simulation Model TWIN-SHIME Shows Differences between Human Urolithin-Metabotypes in Gut Microbiota Composition, Pomegranate Polyphenol Metabolism, and Transport along the Intestinal Tract. Journal of agricultural and food chemistry [Internet]. 2017 [cited 2025 Jan 22];65. Available from: https://pubmed.ncbi.nlm.nih.gov/28616977/
Yasuda T, Takagi T, Asaeda K, Hashimoto H, Kajiwara M, Azuma Y, et al. Urolithin A-mediated augmentation of intestinal barrier function through elevated secretory mucin synthesis. Scientific Reports. 2024;14:1–13.
Singh A, D’Amico D, Andreux PA, Fouassier AM, Blanco-Bose W, Evans M, et al. Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults. Cell reports Medicine [Internet]. 2022 [cited 2025 Jan 22];3. Available from: https://pubmed.ncbi.nlm.nih.gov/35584623/
Liu S, D’Amico D, Shankland E, Bhayana S, Garcia JM, Aebischer P, et al. Effect of Urolithin A Supplementation on Muscle Endurance and Mitochondrial Health in Older Adults: A Randomized Clinical Trial. JAMA network open [Internet]. 2022 [cited 2025 Jan 22];5. Available from: https://pubmed.ncbi.nlm.nih.gov/35050355/
Zhao H, Zhu H, Yun H, Liu J, Song G, Teng J, et al. Assessment of Urolithin A effects on muscle endurance, strength, inflammation, oxidative stress, and protein metabolism in male athletes with resistance training: an 8-week randomized, double-blind, placebo-controlled study. Journal of the International Society of Sports Nutrition [Internet]. 2024 [cited 2025 Jan 22];21. Available from: https://pubmed.ncbi.nlm.nih.gov/39487653/
Jamialahmadi T, Hasanpour M, Vakilian F, Penson PE, Iranshahy M, Sahebkar A. Evaluation of Urolithin A Efficacy in Heart Failure Patients with Reduced Ejection Fraction: A Randomized, Double-blind, Crossover, Placebo-controlled Clinical Trial. Reviews on recent clinical trials [Internet]. 2024 [cited 2025 Jan 22];19. Available from: https://pubmed.ncbi.nlm.nih.gov/38415449/
Haddad EH, Gaban-Chong N, Oda K, Sabaté J. Effect of a walnut meal on postprandial oxidative stress and antioxidants in healthy individuals. Nutrition journal [Internet]. 2014 [cited 2025 Jan 22];13. Available from: https://pubmed.ncbi.nlm.nih.gov/24410903/
Kaplan A, Zelicha H, Yaskolka MA, Rinott E, Tsaban G, Levakov G, et al. The effect of a high-polyphenol Mediterranean diet (Green-MED) combined with physical activity on age-related brain atrophy: the Dietary Intervention Randomized Controlled Trial Polyphenols Unprocessed Study (DIRECT PLUS). The American journal of clinical nutrition [Internet]. 2022 [cited 2025 Jan 22];115. Available from: https://pubmed.ncbi.nlm.nih.gov/35021194/
Zelicha H, Kloting N, Kaplan A, Yaskolka MA, Rinott E, Tsaban G, et al. The effect of high-polyphenol Mediterranean diet on visceral adiposity: the DIRECT PLUS randomized controlled trial. BMC medicine [Internet]. 2022 [cited 2025 Jan 22];20. Available from: https://pubmed.ncbi.nlm.nih.gov/36175997/
Jarrard D, Filon M, Huang W, Havighurst T, DeShong K, Kim K, et al. A phase II randomized placebo-controlled trial of pomegranate fruit extract in men with localized prostate cancer undergoing active surveillance. The Prostate [Internet]. 2021 [cited 2025 Jan 22];81. Available from: https://pubmed.ncbi.nlm.nih.gov/33095939/
Freedland SJ, Carducci M, Kroeger N, Partin A, Rao JY, Jin Y, et al. A double-blind, randomized, neoadjuvant study of the tissue effects of POMx pills in men with prostate cancer before radical prostatectomy. Cancer prevention research (Philadelphia, Pa) [Internet]. 2013 [cited 2025 Jan 22];6. Available from: https://pubmed.ncbi.nlm.nih.gov/23985577/
Selma MV, González-Sarrías A, Salas-Salvadó J, Andrés-Lacueva C, Alasalvar C, Örem A, et al. The gut microbiota metabolism of pomegranate or walnut ellagitannins yields two urolithin-metabotypes that correlate with cardiometabolic risk biomarkers: Comparison between normoweight, overweight-obesity and metabolic syndrome. Clinical nutrition (Edinburgh, Scotland) [Internet]. 2018 [cited 2025 Jan 22];37. Available from: https://pubmed.ncbi.nlm.nih.gov/28347564/
Istas G, Feliciano RP, Weber T, Garcia-Villalba R, Tomas-Barberan F, Heiss C, et al. Plasma urolithin metabolites correlate with improvements in endothelial function after red raspberry consumption: A double-blind randomized controlled trial. Archives of biochemistry and biophysics [Internet]. 2018 [cited 2025 Jan 22];651. Available from: https://pubmed.ncbi.nlm.nih.gov/29802820/
Yaskolka MA, Keller M, Hoffmann A, Rinott E, Tsaban G, Kaplan A, et al. The effect of polyphenols on DNA methylation-assessed biological age attenuation: the DIRECT PLUS randomized controlled trial. BMC medicine [Internet]. 2023 [cited 2025 Jan 22];21. Available from: https://pubmed.ncbi.nlm.nih.gov/37743489/
Targeting aging with urolithin A in humans: A systematic review. Ageing Research Reviews. 2024;100:102406.
Nishimoto Y, Fujisawa K, Ukawa Y, Kudoh M, Funahashi K, Kishimoto Y, et al. Effect of urolithin A on the improvement of vascular endothelial function depends on the gut microbiota. Frontiers in nutrition [Internet]. 2023 [cited 2025 Jan 22];9. Available from: https://pubmed.ncbi.nlm.nih.gov/36687672/
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
