Sound, Safe, Restorative Sleep, Backed By Science
Get Sleep & wake up to the life you’ve been missing
Is It Memory Loss?
Or sleep loss?
Lack of sleep can lead to...
- Impaired memory [1]
- Decreased cognitive ability [2]
- Poor mood [3]
- Imbalanced immune function
- Increased risk of infectious disease [4]
- Vascular inflammation
- Increased risk of cardiovascular disease [5]
- Higher risk of sarcopenia - involuntary loss of muscle mass [6]
- Emotional dysregulation [7]
- Low libido [8]
- Cravings & weight gain [9]
- Metabolic syndrome [10]
- Hormonal imbalances [11]
- Decreased fertility & ability to conceive [12]
"In addition to elevated risks of chronic diseases, short sleep duration is strongly associated with decreases in cognitive performance...
...impairments in several cognitive domains can be observed even after short-term sleep restriction" [13].
Nature Journal, October 2021
Add 4 Pills To Your Night...And Extra Years To Your Life.
Sleep deprivation has deadly consequences, especially for women.
You might feel tired today, but over time, your health takes an enormous hit.
The most impactful illnesses and disasters of the 21st century are linked to lack of sleep.
Incredibly, a follow-up investigation of the space shuttle Challenger disaster named staff sleep loss as a possible cause [14].
The risk of obesity, metabolic syndrome, hypertension, heart attack, stroke, Alzheimer’s disease, and cancer, particularly the increasingly prevalent colorectal cancer, increase with suboptimal sleep [15, 16].
And women are affected more than men.
Females with disturbed sleep have greater chances of cardiovascular disease, increased insulin, hypertension, and inflammation compared to males [17].
Mental health also suffers—symptoms of depression, anxiety, psychosis, and stress perception worsen with sleep loss. Those with insomnia, for instance, have a two-fold risk of developing depression compared to those without the condition [18, 19].
"Sleep is now a non-negotiable part of my health routine—I finally feel good enough to go to Pilates and even babysit my new grand-baby.
I don't feel groggy when I wake up like I did with my prescription sleep meds."
Imagine 8 Restful Hours Instead Of 5 Restless Ones. A Calm Mind Instead Of Racing Thoughts.
The best part? No Rx hangover.
Human Optimization Lab's Sleep may support:
- Non-habit forming REM sleep without the side effects of Rx drugs [20]
- Healthier balance of non-REM and REM sleep patterns [21]
- Sounder sleep versus waking up tired before your alarm clock [22, 23]
- Increased sleep time [22]
- Faster transition from awake to asleep—no more tossing & turning [22]
- Alleviation of insomnia, specifically related to age [22, 24, 25]
- Less chance of waking during the night [26]
- Reduced symptoms of restless legs syndrome [27]
- Antioxidant balance and anti-inflammatory effects [28]
- Reduced anxiety [29]
- Healthier circadian rhythms, even in the presence of unavoidable light at night [30]
- Production of your body's own master antioxidant, melatonin [31]
- Fewer obsessive thoughts that keep you awake [32]
Sleep's dream team:
Melatonin & your mitochondria
When you think of antioxidants, what comes to mind? Most of us imagine berries, dark chocolate, or vitamins C and E. But the real antioxidant all-star? Melatonin. Melatonin is an incredibly potent and unique antioxidant. Why? Unlike other antioxidants, it's created by your mitochondria and plays enormous roles in optimizing their function...and your energy levels [33].
Adequate melatonin:
- Increases the number of mitochondria in each cell
- Regulates mitochondrial fission and fusion, keeping the microscopic organelles healthy and working properly
- Influences mitophagy, the regulated clearing of old or damaged mitochondria
- Modulates all mitochondrial dynamics
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$59 $38.30
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Ingredients Based On Science, Not Social Media.
Sleep is formulated with nutrients and doses proved effective in scientific studies…and only those nutrients.
We don’t believe in proprietary blends or hidden excipients.
Learn more about our transparent, evidence-based ingredients.
Magnesium (Magnesium Glycinate)
Magnesium aids sleep in multiple ways, yet aging is a risk factor for magnesium deficiency. Magnesium relieves muscle tension [35] and is an N-Methyl-D-aspartic acid (NMDA) antagonist and GABA agonist, meaning it gently reduces neuronal excitability and promotes neuronal relaxation.
In a double-blind, randomized trial of people over the age of 60, magnesium supplementation increased sleep time, sleep efficiency, serum renin, the hormone most associated with the REM/NREM sleep cycle, and melatonin while reducing early morning waking and cortisol concentrations [22].
Potassium (Potassium Glycinate)
Sleep is divided into two phases, non-rapid eye movement (NREM) and rapid eye movement (REM) and five separate stages! This organization is called sleep architecture, and potassium is best known for supporting these patterns thanks to its role in regulating the intricate physiology of potassium channels in the nervous system [36].
In one study of 699 hypertensive patients, decreased potassium was linked to disturbed sleep architecture and more sleep disturbances, such as leg movements. Those with efficient potassium levels had greater total sleep time, quicker time falling asleep, higher oxygen saturation, and better sleep efficiency [37].
B6 (Pyridoxal 5’-Phosphate)
Pyridoxal 5′-phosphate (PLP), the biologically active form of vitamin B6, is a cofactor for kynurenine aminotransferase (KAT) and kynureninase (KYNU), two key enzymes in the conversion of kynurenine to tryptophan [38]. In turn, we use tryptophan to make both serotonin and melatonin [39].
PLP has been shown to be beneficial in insomnia, improving sleep quality, reduced night wakings, and, in combination with magnesium, decreased severity of restless leg syndrome and improved sleep quality [27].
Herbatonin® (Plant Melatonin)
Does melatonin leave you feeling drowsy throughout the morning? Interestingly, a double-blind, placebo-controlled study from MIT found 0.3 mg of melatonin to be the ideal dose for people with insomnia over 50 [24]. When compared to the pharmacological dose of 3 mg, the 0.3 physiological dose restored sleep efficiency without remaining elevated into the daytime.
Herbatonin®, a special plant-derived melatonin, offers the added therapeutic benefit of increased antioxidant and anti-inflammatory action versus synthetically-derived melatonin [28].
L-Theanine
L-theanine is a non-protein amino acid abundant in green tea, well known for its relaxing effects and ability to cross the blood-brain barrier [40]. Once in the brain, l-theanine blocks glutamate receptors and enhances GABA and dopamine, resulting in reduced neuro-excitability and increased feelings of relaxation [41].
In a double-blind, randomized control trial of healthy middle-aged adults, L-theanine supplementation helped participants fall asleep more quickly and reduced night wakings, resulting in more restful sleep. Additionally, L-theanine reduced the need for pharmaceutical sleep aids and significantly improved cognitive function [42].
L-Tryptophan
L-tryptophan is an essential amino acid that plays an integral part in nervous system health and is the precursor to serotonin, a key hormone for mood regulation (43). Clinical studies of tryptophan-deficient diets show that low intake of this essential amino acid results in increased depression, anxiety, and poor emotional processing [44].
It is thought that increasing the intake of L-tryptophan via food or supplement may naturally raise serotonin levels, benefit mood, and improve sleep quality.
Isolated pharmaceutical-grade tryptophan and protein-based tryptophan have successfully treated insomnia in adults [45]. A 2022 meta-analysis of studies examining the effects of L- tryptophan supplementation on sleep quality found that tryptophan successfully improved sleep quality by reducing night wakings [46].
L-Serine
L-serine is a non-essential amino acid studied for its remarkable neuroprotective effects [47]. Researchers have hypothesized that dietary L-serine may be responsible for the large centenarian population in Ōgimi, Okinawa, due to their exceptionally high intake of L-serine through foods such as seaweed, tofu, and pork. [48]. The average Ōgimi woman eats over 8 grams of dietary L-serine daily, while her American counterpart only gets 2.5 grams [49].
In addition to its neuroprotective effects, L-serine interacts with the suprachiasmatic nucleus, the master regulator of circadian rhythm, effectively modulating the expression of clock genes [50]. Along with maintaining sleep homeostasis, clock genes play an essential role in learning and memory [51].
Recent studies show that supplementation with l-serine before bedtime significantly enhances dim-light melatonin onset (DLMO), the natural phenomenon that occurs when the pineal gland produces melatonin in response to low light or natural evening light, resulting in optimization of the 24-hour circadian rhythm [52, 53].
5-HTP
5-HTP is an amino acid produced from tryptophan and is a metabolic intermediate to serotonin and melatonin. 5-HTP has been studied for its anti-depressant, anxiolytic, and sleep-promoting effects. Several neurodegenerative diseases have been associated with low levels of 5-HTP, including Parkinson’s, fibromyalgia, and Alzheimer's [54].
A 2021 cross-over study examining the effects of 5-HTP on Parkinson’s disease found that 5-HTP supplementation effectively increased REM sleep in Parkinson’s patients [55].
A randomized control trial of healthy older adults found that supplementing with 100mg of 5-HTP daily significantly improved sleep quality helping them fall asleep an average of 20 minutes earlier than the placebo group [56].
Myo-Inositol
Myo-inositol is a fascinating but commonly underconsumed compound primarily found in organ meats. It was once considered a B vitamin, but its classification changed when endogenous creation from glucose was discovered in the kidneys, liver, and brain.
Unfortunately, insulin resistance and elevated blood sugar reduce our ability to uptake optimal levels of myo-inositol [57].
Its role in sleep is two-fold: It acts directly due to its cellular-level influence on circadian rhythm [58]. However, it also works indirectly via its role in intracellular calcium signaling [59] and the resulting effect on slow wave sleep, aka “deep sleep,” that positively influences memory and immune function.
Chamomile Extract (Matricaria Recutita)
For hundreds of years, chamomile has been one of the most trusted, aromatic sleep herbs. It's properties include anti-anxiety, stress relieving, and anti-insomnia. It's also beneficial to the immune and digestive systems and the liver [60].
Thousands of studies back these traditional uses—chamomile’s primary constituent, apigenin, results in sedative effects due to its interactions with GABA receptors.
In those with primary insomnia, four weeks of supplementation with chamomile extract resulted in better daytime functioning, improved sleep latency, and less nighttime waking, along with a 6.7% decrease in the chamomile group’s Fatigue Severity Scale scores [61].
What people say about Sleep
I have struggled with sleep most of my life, and for the last 10 years have tried many different supplements after finally stopping all sleep medications. Some of these supplements have helped, but I have been using Sleep and find that it combines all the different supplements I have tried into one! It works beautifully, it not only helps me ease into sleep quickly, but when I wake in the middle of the night, I can fall back to sleep. I wake up feeling relaxed but not groggy. I am loving this supplement!!
MP – Sleep
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Buy Sleep Now
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1 Month Supply
Sleep
$59
$59.00 $44.00
Worldwide Shipping (FREE Shipping within the U.S.)*
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3 Month Supply
Sleep
$147
$177.00 $132.00
Worldwide Shipping (FREE Shipping within the U.S.)*
* For international orders: All shipments are shipped Duties, Customs, & Taxes unpaid. Buyer is responsible for delivery fees.
Subscribe & Save
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$59 $44
$59 $38.30
Worldwide Shipping (FREE Shipping within the U.S.)*
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References
All References
- Peng Z, Dai C, Ba Y, Zhang L, Shao Y, Tian J. Effect of Sleep Deprivation on the Working Memory-Related N2-P3 Components of the Event-Related Potential Waveform. Front Neurosci. 2020;14:469.
- Alhola P, Polo-Kantola P. Sleep deprivation: Impact on cognitive performance. Neuropsychiatr Dis Treat. 2007;3(5):553-567.
- Triantafillou S, Saeb S, Lattie EG, Mohr DC, Kording KP. Relationship Between Sleep Quality and Mood: Ecological Momentary Assessment Study. JMIR Ment Health. 2019;6(3):e12613.
- Garbarino S, Lanteri P, Bragazzi NL, Magnavita N, Scoditti E. Role of sleep deprivation in immune-related disease risk and outcomes. Commun Biol. 2021;4(1):1304.
- Hijmans JG, Levy M, Garcia V, et al. Insufficient sleep is associated with a pro-atherogenic circulating microRNA signature. Exp Physiol. 2019;104(6):975-982.
- Li X, He J, Sun Q. Sleep Duration and Sarcopenia: An Updated Systematic Review and Meta-Analysis. J Am Med Dir Assoc. 2023;24(8):1193-1206.e5.
- Saghir Z, Syeda JN, Muhammad AS, Balla Abdalla TH. The Amygdala, Sleep Debt, Sleep Deprivation, and the Emotion of Anger: A Possible Connection?. Cureus. 2018;10(7):e2912.
- Kalmbach DA, Arnedt JT, Pillai V, Ciesla JA. The impact of sleep on female sexual response and behavior: a pilot study. J Sex Med. 2015;12(5):1221-1232.
- Greer SM, Goldstein AN, Walker MP. The impact of sleep deprivation on food desire in the human brain. Nat Commun. 2013;4:2259.
- Chasens ER, Imes CC, Kariuki JK, et al. Sleep and Metabolic Syndrome. Nurs Clin North Am. 2021;56(2):203-217.
- Beroukhim G, Esencan E, Seifer DB. Impact of sleep patterns upon female neuroendocrinology and reproductive outcomes: a comprehensive review. Reprod Biol Endocrinol. 2022;20(1):16.
- Kloss JD, Perlis ML, Zamzow JA, Culnan EJ, Gracia CR. Sleep, sleep disturbance, and fertility in women. Sleep Med Rev. 2015;22:78-87.
- Csipo T, Lipecz A, Owens C, et al. Sleep deprivation impairs cognitive performance, alters task-associated cerebral blood flow and decreases cortical neurovascular coupling-related hemodynamic responses. Sci Rep. 2021;11(1):20994.
- Mitler MM, Dement WC, Dinges DF. Sleep medicine, public policy and public health. In Kryger MH, Roth T, Dement WC (eds). Principles and Practice of Sleep Medicine, 3rd Edition, Philadelphia: WB Saunders, 2000;580-588.
- Medic G, Wille M, Hemels ME. Short- and long-term health consequences of sleep disruption. Nat Sci Sleep. 2017;9:151-161.
- Sabia S, Fayosse A, Dumurgier J, van Hees VT, Paquet C, Sommerlad A, et al. Association of sleep duration in middle and old age with incidence of dementia. Nat Commun. 2021 Apr 20;12(1):2289.
- Suarez EC. Self-reported symptoms of sleep disturbance and inflammation, coagulation, insulin resistance and psychosocial distress: evidence for gender disparity. Brain Behav Immun. 2008;22(6):960-968.
- Scott AJ, Webb TL, Martyn-St James M, Rowse G, Weich S. Improving sleep quality leads to better mental health: A meta-analysis of randomised controlled trials. Sleep Med Rev. 2021;60:101556.
- Baglioni C, Battagliese G, Feige B, et al. Insomnia as a predictor of depression: a meta-analytic evaluation of longitudinal epidemiological studies. J Affect Disord. 2011;135(1-3):10-19.
- Poceta JS. Zolpidem ingestion, automatisms, and sleep driving: a clinical and legal case series. J Clin Sleep Med. 2011;7(6):632-638.
- Benington JH, Woudenberg MC, Heller HC. Apamin, a selective SK potassium channel blocker, suppresses REM sleep without a compensatory rebound. Brain Res. 1995;692(1-2):86-92.
- Abbasi B, Kimiagar M, Sadeghniiat K, Shirazi MM, Hedayati M, Rashidkhani B. The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial. J Res Med Sci. 2012;17(12):1161-1169.
- Sutanto CN, Loh WW, Kim JE. The impact of tryptophan supplementation on sleep quality: a systematic review, meta-analysis, and meta-regression. Nutr Rev. 2022;80(2):306-316.
- Zhdanova IV, Wurtman RJ, Regan MM, Taylor JA, Shi JP, Leclair OU. Melatonin treatment for age-related insomnia. J Clin Endocrinol Metab. 2001;86(10):4727-4730.
- Zick SM, Wright BD, Sen A, Arnedt JT. Preliminary examination of the efficacy and safety of a standardized chamomile extract for chronic primary insomnia: a randomized placebo-controlled pilot study. BMC Complement Altern Med. 2011;11:78.
- Drennan MD, Kripke DF, Klemfuss HA, Moore JD. Potassium affects actigraph-identified sleep. Sleep. 1991;14(4):357-360.
- Jadidi A, Rezaei Ashtiani A, Khanmohamadi Hezaveh A, Aghaepour SM. Therapeutic effects of magnesium and vitamin B6 in alleviating the symptoms of restless legs syndrome: a randomized controlled clinical trial. BMC Complement Med Ther. 2022;23(1):1.
- Kukula-Koch W, Szwajgier D, Gaweł-Bęben K, Strzępek-Gomółka M, Głowniak K, Meissner HO. Is Phytomelatonin Complex Better Than Synthetic Melatonin? The Assessment of the Antiradical and Anti-Inflammatory Properties. Molecules. 2021;26(19):6087.
- Rao TP, Ozeki M, Juneja LR. In Search of a Safe Natural Sleep Aid. J Am Coll Nutr. 2015;34(5):436-447.
- Ohashi M, Lee SI, Eto T, et al. Intake of L-serine before bedtime prevents the delay of the circadian phase in real life. J Physiol Anthropol. 2022;41(1):31.
- Maffei ME. 5-Hydroxytryptophan (5-HTP): Natural Occurrence, Analysis, Biosynthesis, Biotechnology, Physiology and Toxicology. Int J Mol Sci. 2020;22(1):181.
- Harvey BH, Brink CB, Seedat S, Stein DJ. Defining the neuromolecular action of myo-inositol: application to obsessive-compulsive disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2002;26(1):21-32.
- Tan DX, Manchester LC, Qin L, Reiter RJ. Melatonin: A Mitochondrial Targeting Molecule Involving Mitochondrial Protection and Dynamics. Int J Mol Sci. 2016;17(12):2124.
- Reiter RJ, Ma Q, Sharma R. Melatonin in Mitochondria: Mitigating Clear and Present Dangers. Physiology (Bethesda). 2020;35(2):86-95.
- Altura BM, Altura BT. Tension headaches and muscle tension: is there a role for magnesium?. Med Hypotheses. 2001;57(6):705-713.
- Patel AK, Reddy V, Shumway KR, et al. Physiology, Sleep Stages. [Updated 2022 Sep 7]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan.
- Heizhati M, Zhang Y, Shao L, et al. Decreased serum potassium may disturb sleep homeostasis in essential hypertensives. Hypertens Res. 2019;42(2):174-181.
- Deac OM, Mills JL, Shane B, et al. Tryptophan catabolism and vitamin B-6 status are affected by gender and lifestyle factors in healthy young adults. J Nutr. 2015;145(4):701-707.
- Richard DM, Dawes MA, Mathias CW, Acheson A, Hill-Kapturczak N, Dougherty DM. L-Tryptophan: Basic Metabolic Functions, Behavioral Research and Therapeutic Indications. Int J Tryptophan Res. 2009;2:45-60.
- Kimura K, Ozeki M, Juneja LR, Ohira H. L-Theanine reduces psychological and physiological stress responses. Biol Psychol. 2007;74(1):39-45.
- Williams JL, Everett JM, D’Cunha NM, et al. The Effects of Green Tea Amino Acid L-Theanine Consumption on the Ability to Manage Stress and Anxiety Levels: a Systematic Review. Plant Foods Hum Nutr. 2020;75(1):12-23.
- Hidese S, Ogawa S, Ota M, et al. Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial. Nutrients. 2019;11(10):2362.
- Kikuchi AM, Tanabe A, Iwahori Y. A systematic review of the effect of L-tryptophan supplementation on mood and emotional functioning. J Diet Suppl. 2021;18(3):316-333.
- Jenkins TA, Nguyen JC, Polglaze KE, Bertrand PP. Influence of Tryptophan and Serotonin on Mood and Cognition with a Possible Role of the Gut-Brain Axis. Nutrients. 2016;8(1):56.
- Hudson C, Hudson SP, Hecht T, MacKenzie J. Protein source tryptophan versus pharmaceutical grade tryptophan as an efficacious treatment for chronic insomnia. Nutr Neurosci. 2005;8(2):121-127.
- Sutanto CN, Loh WW, Kim JE. The impact of tryptophan supplementation on sleep quality: a systematic review, meta-analysis, and meta-regression. Nutr Rev. 2022;80(2):306-316.
- Ye L, Sun Y, Jiang Z, Wang G. L-Serine, an Endogenous Amino Acid, Is a Potential Neuroprotective Agent for Neurological Disease and Injury. Front Mol Neurosci. 2021;14:726665.
- Cox PA, Metcalf JS. Traditional Food Items in Ogimi, Okinawa: l-Serine Content and the Potential for Neuroprotection. Curr Nutr Rep. 2017;6(1):24-31.
- Yasuo S, Iwamoto A, Lee SI, et al. l-Serine Enhances Light-Induced Circadian Phase Resetting in Mice and Humans. J Nutr. 2017;147(12):2347-2355.
- Bolsius YG, Zurbriggen MD, Kim JK, et al. The role of clock genes in sleep, stress and memory. Biochem Pharmacol. 2021;191:114493.
- Yasuo S, Iwamoto A, Lee SI, et al. l-Serine Enhances Light-Induced Circadian Phase Resetting in Mice and Humans. J Nutr. 2017;147(12):2347-2355.
- Ohashi M, Lee SI, Eto T, et al. Intake of L-serine before bedtime prevents the delay of the circadian phase in real life. J Physiol Anthropol. 2022;41(1):31.
- Maffei ME. 5-Hydroxytryptophan (5-HTP): Natural Occurrence, Analysis, Biosynthesis, Biotechnology, Physiology and Toxicology. Int J Mol Sci. 2020;22(1):181.
- Meloni M, Figorilli M, Carta M, et al. Preliminary finding of a randomized, double-blind, placebo-controlled, crossover study to evaluate the safety and efficacy of 5-hydroxytryptophan on REM sleep behavior disorder in Parkinson’s disease. Sleep Breath. 2022;26(3):1023-1031.
- Sutanto C, Heng CW, Gan AX, Wang X, Fam J, Kim JE. The Impact of 5-Hydroxytryptophan Supplementation on Sleep Quality of Older Adults in Singapore: A Randomized Controlled Trial. Curr Dev Nutr. 2021;5(Suppl 2):372.
- DiNicolantonio JJ, H O’Keefe J. Myo-inositol for insulin resistance, metabolic syndrome, polycystic ovary syndrome and gestational diabetes. Open Heart. 2022;9(1):e001989.
- Wei H, Landgraf D, Wang G, McCarthy MJ. Inositol polyphosphates contribute to cellular circadian rhythms: Implications for understanding lithium’s molecular mechanism. Cell Signal. 2018;44:82-91.
- Bojarskaite L, Bjørnstad DM, Pettersen KH, et al. Astrocytic Ca2+ signaling is reduced during sleep and is involved in the regulation of slow wave sleep. Nat Commun. 2020;11(1):3240.
- Engels G, Brinckmann J. Chamomile Matricaria chamomilla (syn. M. recutita, Chamomilla recutita) Family: Asteraceae. Herbalgram. 2023;108:8-17.
- Zick SM, Wright BD, Sen A, Arnedt JT. Preliminary examination of the efficacy and safety of a standardized chamomile extract for chronic primary insomnia: a randomized placebo-controlled pilot study. BMC Complement Altern Med. 2011;11:78.
- Peng Z, Dai C, Ba Y, Zhang L, Shao Y, Tian J. Effect of Sleep Deprivation on the Working Memory-Related N2-P3 Components of the Event-Related Potential Waveform. Front Neurosci. 2020;14:469.
- Alhola P, Polo-Kantola P. Sleep deprivation: Impact on cognitive performance. Neuropsychiatr Dis Treat. 2007;3(5):553-567.
- Triantafillou S, Saeb S, Lattie EG, Mohr DC, Kording KP. Relationship Between Sleep Quality and Mood: Ecological Momentary Assessment Study. JMIR Ment Health. 2019;6(3):e12613.
- Garbarino S, Lanteri P, Bragazzi NL, Magnavita N, Scoditti E. Role of sleep deprivation in immune-related disease risk and outcomes. Commun Biol. 2021;4(1):1304.
- Hijmans JG, Levy M, Garcia V, et al. Insufficient sleep is associated with a pro-atherogenic circulating microRNA signature. Exp Physiol. 2019;104(6):975-982.
- Li X, He J, Sun Q. Sleep Duration and Sarcopenia: An Updated Systematic Review and Meta-Analysis. J Am Med Dir Assoc. 2023;24(8):1193-1206.e5.
- Saghir Z, Syeda JN, Muhammad AS, Balla Abdalla TH. The Amygdala, Sleep Debt, Sleep Deprivation, and the Emotion of Anger: A Possible Connection?. Cureus. 2018;10(7):e2912.
- Kalmbach DA, Arnedt JT, Pillai V, Ciesla JA. The impact of sleep on female sexual response and behavior: a pilot study. J Sex Med. 2015;12(5):1221-1232.
- Greer SM, Goldstein AN, Walker MP. The impact of sleep deprivation on food desire in the human brain. Nat Commun. 2013;4:2259.
- Chasens ER, Imes CC, Kariuki JK, et al. Sleep and Metabolic Syndrome. Nurs Clin North Am. 2021;56(2):203-217.
- Beroukhim G, Esencan E, Seifer DB. Impact of sleep patterns upon female neuroendocrinology and reproductive outcomes: a comprehensive review. Reprod Biol Endocrinol. 2022;20(1):16.
- Kloss JD, Perlis ML, Zamzow JA, Culnan EJ, Gracia CR. Sleep, sleep disturbance, and fertility in women. Sleep Med Rev. 2015;22:78-87.
- Csipo T, Lipecz A, Owens C, et al. Sleep deprivation impairs cognitive performance, alters task-associated cerebral blood flow and decreases cortical neurovascular coupling-related hemodynamic responses. Sci Rep. 2021;11(1):20994.
- Mitler MM, Dement WC, Dinges DF. Sleep medicine, public policy and public health. In Kryger MH, Roth T, Dement WC (eds). Principles and Practice of Sleep Medicine, 3rd Edition, Philadelphia: WB Saunders, 2000;580-588.
- Medic G, Wille M, Hemels ME. Short- and long-term health consequences of sleep disruption. Nat Sci Sleep. 2017;9:151-161.
- Sabia S, Fayosse A, Dumurgier J, van Hees VT, Paquet C, Sommerlad A, et al. Association of sleep duration in middle and old age with incidence of dementia. Nat Commun. 2021 Apr 20;12(1):2289.
- Suarez EC. Self-reported symptoms of sleep disturbance and inflammation, coagulation, insulin resistance and psychosocial distress: evidence for gender disparity. Brain Behav Immun. 2008;22(6):960-968.
- Scott AJ, Webb TL, Martyn-St James M, Rowse G, Weich S. Improving sleep quality leads to better mental health: A meta-analysis of randomised controlled trials. Sleep Med Rev. 2021;60:101556.
- Baglioni C, Battagliese G, Feige B, et al. Insomnia as a predictor of depression: a meta-analytic evaluation of longitudinal epidemiological studies. J Affect Disord. 2011;135(1-3):10-19.
- Poceta JS. Zolpidem ingestion, automatisms, and sleep driving: a clinical and legal case series. J Clin Sleep Med. 2011;7(6):632-638.
- Benington JH, Woudenberg MC, Heller HC. Apamin, a selective SK potassium channel blocker, suppresses REM sleep without a compensatory rebound. Brain Res. 1995;692(1-2):86-92.
- Abbasi B, Kimiagar M, Sadeghniiat K, Shirazi MM, Hedayati M, Rashidkhani B. The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial. J Res Med Sci. 2012;17(12):1161-1169.
- Sutanto CN, Loh WW, Kim JE. The impact of tryptophan supplementation on sleep quality: a systematic review, meta-analysis, and meta-regression. Nutr Rev. 2022;80(2):306-316.
- Zhdanova IV, Wurtman RJ, Regan MM, Taylor JA, Shi JP, Leclair OU. Melatonin treatment for age-related insomnia. J Clin Endocrinol Metab. 2001;86(10):4727-4730.
- Zick SM, Wright BD, Sen A, Arnedt JT. Preliminary examination of the efficacy and safety of a standardized chamomile extract for chronic primary insomnia: a randomized placebo-controlled pilot study. BMC Complement Altern Med. 2011;11:78.
- Drennan MD, Kripke DF, Klemfuss HA, Moore JD. Potassium affects actigraph-identified sleep. Sleep. 1991;14(4):357-360.
- Jadidi A, Rezaei Ashtiani A, Khanmohamadi Hezaveh A, Aghaepour SM. Therapeutic effects of magnesium and vitamin B6 in alleviating the symptoms of restless legs syndrome: a randomized controlled clinical trial. BMC Complement Med Ther. 2022;23(1):1.
- Kukula-Koch W, Szwajgier D, Gaweł-Bęben K, Strzępek-Gomółka M, Głowniak K, Meissner HO. Is Phytomelatonin Complex Better Than Synthetic Melatonin? The Assessment of the Antiradical and Anti-Inflammatory Properties. Molecules. 2021;26(19):6087.
- Rao TP, Ozeki M, Juneja LR. In Search of a Safe Natural Sleep Aid. J Am Coll Nutr. 2015;34(5):436-447.
- Ohashi M, Lee SI, Eto T, et al. Intake of L-serine before bedtime prevents the delay of the circadian phase in real life. J Physiol Anthropol. 2022;41(1):31.
- Maffei ME. 5-Hydroxytryptophan (5-HTP): Natural Occurrence, Analysis, Biosynthesis, Biotechnology, Physiology and Toxicology.
Int J Mol Sci. 2020;22(1):181. - Harvey BH, Brink CB, Seedat S, Stein DJ. Defining the neuromolecular action of myo-inositol: application to obsessive-compulsive disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2002;26(1):21-32.
- Tan DX, Manchester LC, Qin L, Reiter RJ. Melatonin: A Mitochondrial Targeting Molecule Involving Mitochondrial Protection and Dynamics. Int J Mol Sci. 2016;17(12):2124.
- Reiter RJ, Ma Q, Sharma R. Melatonin in Mitochondria: Mitigating Clear and Present Dangers. Physiology (Bethesda). 2020;35(2):86-95.
- Altura BM, Altura BT. Tension headaches and muscle tension: is there a role for magnesium?. Med Hypotheses. 2001;57(6):705-713.
- Patel AK, Reddy V, Shumway KR, et al. Physiology, Sleep Stages. [Updated 2022 Sep 7]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan.
- Heizhati M, Zhang Y, Shao L, et al. Decreased serum potassium may disturb sleep homeostasis in essential hypertensives. Hypertens Res. 2019;42(2):174-181.
- Deac OM, Mills JL, Shane B, et al. Tryptophan catabolism and vitamin B-6 status are affected by gender and lifestyle factors in healthy young adults. J Nutr. 2015;145(4):701-707.
- Richard DM, Dawes MA, Mathias CW, Acheson A, Hill-Kapturczak N, Dougherty DM. L-Tryptophan: Basic Metabolic Functions, Behavioral Research and Therapeutic Indications. Int J Tryptophan Res. 2009;2:45-60.
- Kimura K, Ozeki M, Juneja LR, Ohira H. L-Theanine reduces psychological and physiological stress responses. Biol Psychol. 2007;74(1):39-45.
- Williams JL, Everett JM, D’Cunha NM, et al. The Effects of Green Tea Amino Acid L-Theanine Consumption on the Ability to Manage Stress and Anxiety Levels: a Systematic Review. Plant Foods Hum Nutr. 2020;75(1):12-23.
- Hidese S, Ogawa S, Ota M, et al. Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial. Nutrients. 2019;11(10):2362.
- Kikuchi AM, Tanabe A, Iwahori Y. A systematic review of the effect of L-tryptophan supplementation on mood and emotional functioning. J Diet Suppl. 2021;18(3):316-333.
- Jenkins TA, Nguyen JC, Polglaze KE, Bertrand PP. Influence of Tryptophan and Serotonin on Mood and Cognition with a Possible Role of the Gut-Brain Axis. Nutrients. 2016;8(1):56.
- Hudson C, Hudson SP, Hecht T, MacKenzie J. Protein source tryptophan versus pharmaceutical grade tryptophan as an efficacious treatment for chronic insomnia. Nutr Neurosci. 2005;8(2):121-127.
- Sutanto CN, Loh WW, Kim JE. The impact of tryptophan supplementation on sleep quality: a systematic review, meta-analysis, and meta-regression. Nutr Rev. 2022;80(2):306-316.
- Ye L, Sun Y, Jiang Z, Wang G. L-Serine, an Endogenous Amino Acid, Is a Potential Neuroprotective Agent for Neurological Disease and Injury. Front Mol Neurosci. 2021;14:726665.
- Cox PA, Metcalf JS. Traditional Food Items in Ogimi, Okinawa: l-Serine Content and the Potential for Neuroprotection. Curr Nutr Rep. 2017;6(1):24-31.
- Yasuo S, Iwamoto A, Lee SI, et al. l-Serine Enhances Light-Induced Circadian Phase Resetting in Mice and Humans. J Nutr. 2017;147(12):2347-2355.
- Bolsius YG, Zurbriggen MD, Kim JK, et al. The role of clock genes in sleep, stress and memory. Biochem Pharmacol. 2021;191:114493.
- Yasuo S, Iwamoto A, Lee SI, et al. l-Serine Enhances Light-Induced Circadian Phase Resetting in Mice and Humans. J Nutr. 2017;147(12):2347-2355.
- Ohashi M, Lee SI, Eto T, et al. Intake of L-serine before bedtime prevents the delay of the circadian phase in real life. J Physiol Anthropol. 2022;41(1):31.
- Maffei ME. 5-Hydroxytryptophan (5-HTP): Natural Occurrence, Analysis, Biosynthesis, Biotechnology, Physiology and Toxicology. Int J Mol Sci. 2020;22(1):181.
- Meloni M, Figorilli M, Carta M, et al. Preliminary finding of a randomized, double-blind, placebo-controlled, crossover study to evaluate the safety and efficacy of 5-hydroxytryptophan on REM sleep behavior disorder in Parkinson’s disease. Sleep Breath. 2022;26(3):1023-1031.
- Sutanto C, Heng CW, Gan AX, Wang X, Fam J, Kim JE. The Impact of 5-Hydroxytryptophan Supplementation on Sleep Quality of Older Adults in Singapore: A Randomized Controlled Trial. Curr Dev Nutr. 2021;5(Suppl 2):372.
- DiNicolantonio JJ, H O’Keefe J. Myo-inositol for insulin resistance, metabolic syndrome, polycystic ovary syndrome and gestational diabetes. Open Heart. 2022;9(1):e001989.
- Wei H, Landgraf D, Wang G, McCarthy MJ. Inositol polyphosphates contribute to cellular circadian rhythms: Implications for understanding lithium’s molecular mechanism. Cell Signal. 2018;44:82-91.
- Bojarskaite L, Bjørnstad DM, Pettersen KH, et al. Astrocytic Ca2+ signaling is reduced during sleep and is involved in the regulation of slow wave sleep. Nat Commun. 2020;11(1):3240.
- Engels G, Brinckmann J. Chamomile Matricaria chamomilla (syn. M. recutita, Chamomilla recutita) Family: Asteraceae. Herbalgram. 2023;108:8-17.
- Zick SM, Wright BD, Sen A, Arnedt JT. Preliminary examination of the efficacy and safety of a standardized chamomile extract for chronic primary insomnia: a randomized placebo-controlled pilot study. BMC Complement Altern Med. 2011;11:78.
