Human Optimization Is The New Brand Of The Energy Blueprint
The Premium, Next-Generation Nootropic Supplement That's Packed With The Nutrition Your Brain Needs To Heal And Function At Its Full Power
What You Can Expect From UltraBrain
- Improved mood (combat depressed mood and increase joy)
- Improved focus and cognitive performance
- Improved brain energy levels
- Decreased brain fog (improved clarity)
- Decreased anxiety
- Stimulant-free brain boosting action
- Long-term decreased risk of neurodegenerative diseases
Do You Have Any (Or All) Of These Symptoms?
- Brain-Related fatigue - Feeling fatigued, exhausted, or sleepy after doing something mentally demanding
- Chronic low-energy - waking up feeling groggy, feeling tired throughout the day, relying on caffeine or stimulants to keep you alert
- Brain fog - a type of cognitive dysfunction that includes memory problems, lack of ability to concentrate, and lack of mental clarity
- Anxiety or depression - persistent feelings of sadness, emptiness, guilt, hopelessness, worry, or pessimism
- Sleep problems - racing thoughts at bedtime or inability to fall asleep quickly, waking up in the night - sometimes repeatedly, insomnia
- Loss of resiliency - inability to handle and recover from stress
Whether you suffer from one or all of these issues, you must understand this critical truth: These symptoms are NOT a normal thing, and they're NOT just a normal part of aging!
Here's The Reality
These symptoms are present because you actually have damaged, inflamed, or dysfunctional neurons in your brain more specifically, you have:
Leaky blood-brain barrier – a shockingly common issue where the protective wall between your brain and bloodstream breaks down when it becomes leaky, things get into the brain that shouldn’t be there.
Mitochondrial dysfunction/shutdown – mitochondria are your cellular energy generators and danger sensors, but, mitochondria cannot be in both energy mode and cell defense mode. When your mitochondria are weak, they are constantly trying to sense danger and can’t produce energy.
Neuroinflammation – cells in your brain called microglia, which sort of function as your brain’s immune system, are activated too frequently and become stuck in the on position, as a result, they produce inflammatory compounds and oxidative damage.
Let's Fix The Damaged Neurons in Your Brain!
You CAN seal your blood-brain barrier, heal your mitochondria, and reduce the inflammation in your brain!
You CAN reverse your brain-related fatigue, brain fog, anxiety and depression, loss of resilience, and sleep issues!
To do this you must:
- Nourish your imbalanced brain with a wide range of nutrients – nutrients that are scientifically proven to fix your neurons
- Reverse cellular dysfunction
- Reduce inflammation
- Rewire your brain out of fatigue, stress, and depression mode
Buy UltraBrain Now
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$99.00 $74.00
Worldwide Shipping (FREE Shipping within the U.S.)*
* For international orders: All shipments are shipped Duties, Customs, & Taxes unpaid. Buyer is responsible for delivery fees.
3 Month Supply
UltraBrain
$249
Worldwide Shipping (FREE Shipping within the U.S.)*
* For international orders: All shipments are shipped Duties, Customs, & Taxes unpaid. Buyer is responsible for delivery fees.
Worldwide Shipping (FREE Shipping within the U.S.)*
* For international orders: All shipments are shipped Duties, Customs, & Taxes unpaid. Buyer is responsible for delivery fees.
Buy UltraBrain Now
1 Month Supply
UltraBrain
$99 $74.00
Worldwide Shipping (FREE Shipping within the U.S.)*
* For international orders: All shipments are shipped Duties, Customs, & Taxes unpaid. Buyer is responsible for delivery fees.
Subscribe & Save
UltraBrain
$99.00 $64.35
Worldwide Shipping (FREE Shipping within the U.S.)*
* For international orders: All shipments are shipped Duties, Customs, & Taxes unpaid. Buyer is responsible for delivery fees.
3 Month Supply
UltraBrain
$297 $222
Worldwide Shipping (FREE Shipping within the U.S.)*
* For international orders: All shipments are shipped Duties, Customs, & Taxes unpaid. Buyer is responsible for delivery fees.
Worldwide Shipping (FREE Shipping within the U.S.)*
* For international orders: All shipments are shipped Duties, Customs, & Taxes unpaid. Buyer is responsible for delivery fees.
What people say about UltraBrain
I’ve tried a number of nootropics, including Qualia, and Ultrabrain is the best I’ve ever tried. I’ve only used for 3 days but looking forward to trialing over a longer period of time.
Jason – UltraBrain
I started mine 4 days ago, and can tell a difference in energy with just 4 capsules.
Maureen – UltraBrain
I really love Ultrabrain!!! I’ve only been taking it for a little more than a week, yet I began noticing lessened depression, less anxiety, remembering more. Thank you so much for offering this product!
Beth – UltraBrain
I have to say, I am really very seriously impressed with Ultrabrain. I feel clearer, and I even LOOK clearer…Interestingly, unexpectedly, my skin looks rosier, I have good color, I look less tired and I FEEL less tired. Not sure what the color in my face is from, does anyone know?) but I like it.
Getty – UltraBrain
I just want Ultrabrain back in stock again <3 it's made such a difference for me and can't wait to take it again. My Hormone issues were helped by it as well as anxiety, better brain function etc A sleep formula would be nice.
Bonnie – UltraBrain
Really loving your new Ultrabrain product! It’s also much better than Qualia.
Tim – UltraBrain
I have been using the UltraBrain Product for about a year and a half now. I will be 79 in early April and attribute my ability to still take on major Power Industry Projects, largely on account of the positive effects that UltraBrain has on my mental clarity and perception abilities. (I began noticing a positive difference in my cognitive skills after around 3.5 – 4 months of using your product.)
James L – UltraBrain
This could be your testimony here.
Your Testimony – UltraBrain
The Perfect Formulation
15 Premium, carefully sourced ingredients in effective dosages.
Rhodiola Rosea
Rhodiola is a neuroprotective, cognitive enhancing, and mood stabilizing herb that promotes neuronal regeneration, functions as an antioxidant and anti-inflammatory, facilitates neurotransmission, and regulates several key mediators of the stress response [1–3].
The effects are rapid. In adults with chronic work- and life-related stress, rhodiola significantly reduced feelings of exhaustion, irritability, and anxiety in as little as three days [4].
In a study of working adults suffering from burnout, a third of whom had been unsuccessfully treated for their stress in the past, rhodiola improved every aspect of quality of life and perceived stress after just 1 week, with further improvements seen after 12 weeks [5].
In adults with chronic fatigue syndrome, rhodiola improved every aspect of fatigue after just 1 week, with further improvements seen after 8 weeks [6]. Ultimately, 83% of the participants reported “very much” or “much” improved conditions, with every aspect of fatigue, stress, and global impairment being cut in half.
Improvements in perceived stress, mental fatigue, cognitive performance, anxiety, and depression have also been noted in medical students [7], military cadets [8], and adults with stress-related fatigue [9], mild anxiety [10], and mild-to-moderate depression [11,12].
- Stabilizes mood
- Reduces anxiety and depression
- Improves cognitive performance
- Reduces feelings of exhaustion, irritability, and burnout
- Increases resilience (resistance to stress)
- Functions as an antioxidant and anti-inflammatory
- Fast-acting
In adults with chronic fatigue syndrome, rhodiola improved every aspect of fatigue after just 1 week, with further improvements seen after 8 weeks [6]. Ultimately, 83% of the participants reported “very much” or “much” improved conditions, with every aspect of fatigue, stress, and global impairment being cut in half.
Improvements in perceived stress, mental fatigue, cognitive performance, anxiety, and depression have also been noted in medical students [7], military cadets [8], and adults with stress-related fatigue [9], mild anxiety [10], and mild-to-moderate depression [11,12]. 
Lion's Mane Powder
Lion’s mane mushroom (Yamabushitake or Hericium erinaceus) is a medicinal mushroom that has been extensively studied for its neurohealth properties [13,14].
- Stimulates the production of nerve growth factor [15–17], which promotes neuronal growth, development, and regeneration [18].
- Stimulates the production of brain derived neurotrophic factor [19], which has neuroprotective effects, plays a role in neuronal development, and helps in the formation of neuronal connections important for memory and cognition [20].
- Restores levels of serotonin, noradrenaline, and dopamine levels in the brain that can be suppressed due to chronic stress [19].
- Reduces neuroinflammation [19,21]
Clinical trials have shown that lion’s mane improves cognitive function by 12% compared to placebo in older adults with mild cognitive impairment [22], and reduces symptoms of anxiety (by 27%) and depression (by 39%) in adults with obesity [23].
- Reduces anxiety and depression
- Helps improve memory, concentration, and overall cognitive function
- Promotes nerve growth and regeneration in the brain
- Reduces inflammation
- Stabilizes mood
- Restores key neurotransmitters
Alpha-GPC
Alpha-glycerophosphocholine (Alpha-GPC) is a highly bioavailable source of choline for the brain [24], which plays a critical role in neuronal plasticity, membrane stability, signaling events, and neurotransmission [25].
- Protects neurons in the brain and supports neurotransmission
- Increases dopamine and serotonin signaling in the brain
- Decreases risk of vascular dementia
- More effective than Alzheimer drug (Aricept) at improving cognition
Having adequate brain choline concentrations is neuroprotective against a variety of brain diseases [26], and numerous clinical trials have found that alpha-GPC improves cognitive function and memory in individuals with neurodegenerative disorders, vascular dementia, and stroke — even being more effective than the standard drug therapy for Alzheimer’s disease [27].
Choline (Cognizin®)
CDP-choline is a bioavailable source of choline for the brain and the direct precursor for the synthesis of phosphatidylcholine [28,29], one of the most abundant and important structural components of cell membranes. Supplementation has been confirmed in humans to increase phosphatidylcholine synthesis within the brain [30,31].
A Cochrane Systematic Review of 14 double-blind, placebo-controlled trials involving older adults with cognitive deficits like dementia reported that CDP-choline was able to improve memory, correct abnormal behaviors, and increase the global impression that physicians have towards the participants [32].
Other studies have found that CDP-choline slows the deterioration of cognition in those with Alzheimer’s disease [33,34], improves motor function and attention in adolescents [35], and improves attention in healthy women [36].
- Promotes the health of cell membranes
- Improves memory and overall brain cognition
- Improves motor function
- Increases focus and reduces impulsive behavior
- Improves neuroplasticity (helps the brain adapt to new situations)
Bacopa
Bacopa monnieri is an Ayurvedic swamp plant (Brahmi) traditionally used for the enhancement of memory and cognition, as well as a general brain tonic. Its bioactive constituents, the bacosides, have numerous biological effects within the brain that facilitate this use [37–41]:
- Reduces oxidative stress and increases antioxidant enzyme activity
- Reduces inflammation
- Neuroprotective
- Reduces β-amyloid deposition
- Increases the growth of nerve endings to enhance neuronal communication
- Increase blood flow and the delivery of oxygen and nutrients
- Enhances short-term and long-term memory
- Enhances learning, visual processing, cognitive performance
- Improves mood and reduces depression and anxiety
- Reduces oxidative stress
- Neuroprotective
- Reduces β-amyloid deposits
- Enhances communication between neurons
- Increases blood flow
Ginkgo Biloba
Ginkgo biloba possesses neuroprotective and antioxidant effects that preserve brain receptors susceptible to age-related loss, counteract cognitive impairment, enhance neuronal plasticity, and improve memory [49].
- Neuroprotective
- Improves memory and cognitive performance
- Works as an antioxidant
- Counteracts cognitive impairment
- Improves neuroplasticity
- Preserves brain receptors in aging adults
A systematic review of 12 meta-analyses found that ginkgo biloba improves cognitive performance, activities of daily living, and clinical global impression in the treatment of dementia [50], provided that at least 240 mg was used daily for several months [51]. 
Coffee Fruit (CognatiQ™)
CognatiQ™ is a patented extract of the whole coffee fruit, including both the coffee bean and the fruiting body surrounding it, which contains many powerful antioxidant compounds [52,53].
Clinical studies in healthy adults have shown that CognatiQ™ nearly doubles concentrations of brain-derived neurotrophic factor (BDNF) after 1–2 hours [54,55], beating out other forms of coffee bioactives, caffeine, and the phytochemical-rich grape seed extract.
BDNF is a key protein involved in brain health, well established to be critical for:
- Increases Brain-Derived Neurotrophic Factor (BDNF)
- Powerful antioxidant
- Improves neuroplasticity
- Helps to grow new neurons and prevent neurodegeneration
- Improves long-term memory
BDNF is a key protein involved in brain health, well established to be critical for:
- Neuroplasticity (helps the brain adapt to new situations) [56].
- Neurogenesis (the growth, regeneration and creation of new neurons and synapses) [57,58].
- Long-term memory [59].
- Prevention of neurodegeneration [60].
Huperzine A
Huperzine-A is a naturally occurring acetylcholinesterase inhibitor, which functions to inhibit the enzyme that degrades acetylcholine, the neurotransmitter responsible for learning new information [61].
A meta-analysis of 20 randomized controlled trials found that huperzine A supplementation improves cognitive function, daily living activity, and global clinical assessments over 8–36 weeks [62]. Other meta-analyses have reported that huperzine A improves cognition in those with vascular dementia [63], as well as in those with major depression [64].
- Promotes learning
- Used for centuries to treat brain-based illnesses
- Improves cognition, especially in people with Alzheimer’s and vascular dementia
- Naturally occurring acetylcholinesterase inhibitor (primary class of drugs for treating Alzheimer’s and dementia)
Acetyl-L Carnitine
Acetyl-L-Carnitine (ALCAR) is a special form of carnitine that achieves two goals: (1) it supplies the carnitine your mitochondria need to produce energy, and (2) it provides an acetyl moiety that your mitochondria use to remain youthful and healthy.
ALCAR easily crosses the blood-brain barrier and preserves mitochondrial function within the brain that otherwise deteriorates with aging [65–69]. Notably, ALCAR concentrations slowly decline as cognitive impairment progresses, ultimately being 36% lower in Alzheimer’s patients than healthy adults [70].
A meta-analysis of 21 randomized controlled trials involving patients with mild cognitive impairment or Alzheimer’s disease found that ALCAR significantly improved cognitive function and prevented the progression of Alzheimer’s after as little as 3 months [71].
In elderly adults suffering from excessive fatigue, ALCAR improved cognitive function by 15%, reduced mental and physical fatigue by 43–52%, and improved the ability to function in daily life by 24% [72].
A meta-analysis of 12 randomized controlled trials found 3 g/d of ALCAR to significantly reduce depressive symptoms with an efficacy similar to antidepressant drugs, but with far less side effects [73].
- Improves brain function, especially memory and attention
- Reduces oxidative stress
- Protects against β-amyloid neurotoxicity
- Reduces mental and physical fatigue
- Reduces depression – more effective than antidepressant drugs! (And with far fewer side effects)
- Reduces pain and increases nerve conduction
- Prevents progression of brain-related disease
A meta-analysis of 21 randomized controlled trials involving patients with mild cognitive impairment or Alzheimer’s disease found that ALCAR significantly improved cognitive function and prevented the progression of Alzheimer’s after as little as 3 months [71].
In elderly adults suffering from excessive fatigue, ALCAR improved cognitive function by 15%, reduced mental and physical fatigue by 43–52%, and improved the ability to function in daily life by 24% [72].
A meta-analysis of 12 randomized controlled trials found 3 g/d of ALCAR to significantly reduce depressive symptoms with an efficacy similar to antidepressant drugs, but with far less side effects [73].
Saffron Extract
Saffron is one of the most well-researched antidepressant compounds available, with three separate meta-analyses of randomized controlled trials indicating that 30 mg/d has a potency comparable to prescription drugs but with less side effects [74–76].
Other studies have shown that saffron is as effective as prescription drugs for treating obsessive compulsive disorder (OCD) [77], and boosts cognitive function to the same extent as prescription drugs in those with Alzheimer’s disease [78,79].
As effective as prescription drugs (with less side effects) in:
- Reducing depression Treating obsessive compulsive disorder (OCD)
- Improving cognitive function
- Antioxidant and anti-inflammatory
- Neuroprotective
L-Theanine
L-theanine is a naturally occurring amino acid found in tea that alters neurotransmitter signaling within the brain. After consumption, it crosses the blood-brain barrier, interferes with excitatory glutamate signaling, stimulates dopamine release, and promotes inhibitory neurotransmission, thereby helping promote a state of relaxation [80,81].
Electroencephalography (EEG) studies have shown that theanine shifts brain waves towards alpha oscillatory patterns indicative of a relaxed state, particularly in those with high levels of baseline anxiety [82–86]. Accordingly, several studies have found that theanine supplementation improves feelings of relaxation, tension, calmness, and anxiety in the hours following [87,88].
Agmatine Sulfate
Agmatine is a neurotransmitter and neuromodulator (affects neurotransmission of entire neurons) that has anti-seizure, anti-pain, anti-anxiety, and antidepressant effects; modulates some of the processes involved in learning and memory; and interacts with the mechanisms of drug withdrawal [89].
Preliminary research has shown that agmatine supplementation causes a “total/incontrovertible remission of depression” without apparent adverse effects in those who were not responsive to conventional treatments [90].
In a randomized, double-blind, placebo-controlled study of individuals with back pain from herniated lumbar discs, agmatine reduced pain by 25–28% and improved parameters of general health by 65–76% after just two weeks [91].
- Important neurotransmitter
- Improves learning and memory
- Reduces anxiety and depression
- Protects neurons and enhances cell growth
- Protects mitochondria
- More effective at relieving pain than conventional medications
Polygala Tenuifolia
Polygala tenuifolia is one of the fundamental herbs used in traditional Chinese medicine, used to improve memory and combat forgetfulness with aging [92], which it does by:
- Inhibiting the breakdown of acetylcholine, dopamine, serotonin, and noradrenaline, neurotransmitters required for learning new information, memory storage, and overall mental health [93,94].
- Increasing the expression of brain derived neurotrophic factor (BDNF), which is fundamental for neuroplasticity and neurogenesis [95].
- Promoting the growth of new neurons in the brain [96].
- Improves memory and combats forgetfulness
- Supports neurotransmitters required for learning, memory, and mental health
- Promotes growth of new neurons in the brain
- Increases neuroplasticity and cognitive function
N-Acetyl-L-Tyrosine
L-tyrosine is a conditionally essential amino acid that serves as the precursor molecule from which we create the catecholamines: dopamine, adrenaline, and noradrenaline. Your brain needs a steady supply of tyrosine to make the catecholamines and keep your mental health at its peak [99,100], particularly if you are under a lot of stress [101].
Several clinical trials have shown that L-tyrosine supplementation boosts cognition, alertness, and memory in stressful and demanding situations in otherwise healthy adults [102,103], such as those who skimp on their sleep [104], undergo intense physical training [105], or those who endure extreme temperatures [106].
- Critical for stress management
- Boosts cognition, alertness, and information processing
- Improves memory and mental health
Magnesium Taurate
Magnesium is required for over 300 enzymes to function properly [107]. Within the brain and nervous system, magnesium is required for optimal nerve transmission and protection against excitotoxicity (excessive excitation leading to cell death) [108,109].
A systematic review of magnesium’s role in neurological disorders found that it plays an important role in the prevention of migraines, treatment of anxiety and depression, severity of Parkinson’s disease, development of Alzheimer’s disease, and protection against stroke [110].
But, not all forms of magnesium are the same. Magnesium taurate demonstrates a superior ability to enter into the brain and increase the brain’s magnesium status compared to other forms [111,112].
- Over 300 enzymes require magnesium to function properly!
- Required for optimal nerve transmission Protects against cell death
- Prevents mitochondrial dysfunction
- Prevents migraines Improves anxiety and depression
- Slows development of and severity of Parkinson’s and Alzheimer’s
- Reduces risk of stroke
Why These Specific Nutrients?
The result is a very carefully curated formulation that meets these unparalleled standards:
- Absolutely zero pseudo-sciences, facts, or false marketing. Pure science in every serving
- Each ingredient is in its most potent, bioavailable form. Really nothing else can outperform these brain-boosting compounds.
- Effective dosages in each and every serving. 6 capsules a day is everything you need to help reverse cellular dysfunction and supercharge your mental capacity
Buy UltraBrain Now
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* For international orders: All shipments are shipped Duties, Customs, & Taxes unpaid. Buyer is responsible for delivery fees.
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* For international orders: All shipments are shipped Duties, Customs, & Taxes unpaid. Buyer is responsible for delivery fees.
3 Month Supply
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$249
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* For international orders: All shipments are shipped Duties, Customs, & Taxes unpaid. Buyer is responsible for delivery fees.
Worldwide Shipping (FREE Shipping within the U.S.)*
* For international orders: All shipments are shipped Duties, Customs, & Taxes unpaid. Buyer is responsible for delivery fees.
Buy UltraBrain Now
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UltraBrain
$99 $74.00
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* For international orders: All shipments are shipped Duties, Customs, & Taxes unpaid. Buyer is responsible for delivery fees.
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UltraBrain
$99.00 $64.35
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* For international orders: All shipments are shipped Duties, Customs, & Taxes unpaid. Buyer is responsible for delivery fees.
3 Month Supply
UltraBrain
$297 $222
Worldwide Shipping (FREE Shipping within the U.S.)*
* For international orders: All shipments are shipped Duties, Customs, & Taxes unpaid. Buyer is responsible for delivery fees.
Worldwide Shipping (FREE Shipping within the U.S.)*
* For international orders: All shipments are shipped Duties, Customs, & Taxes unpaid. Buyer is responsible for delivery fees.
How UltraBrain Helps
The specific stack of ingredients in UltraBrain work together to stimulate your brain in multiple ways:
Brain Balance
Maintain an even, joyful mood
Eliminate depression and anxiety
Feel happy, optimistic, and grateful
Brain Strength
Handle and recover from stress better
Bounce back faster
Become less fragile and anxious
Brain Energy
Boost alertness, stamina, and energy
Accomplish mentally demanding tasks without feeling tired
Formulated to Give You Your Youthful, Alert, Energetic Brain Back
The 15 science-backed ingredients - in effective dosages in each serving - will help heal your brain, allowing your cognitive function to reach its full potential.
What Happens After Just A Few Daily Doses?
You’ll notice dramatic improvements in your mental performance and will be able to:
- Shut down neuroinflammation – and increase mitochondrial health in the brain, supercharging your brain cell communication and stopping brain-related fatigue.
- Repair neurotransmitter imbalances – positively impacting your cognitive function and learning, your mood and ability to feel joy, your sense of relaxation and calm, your stress response and tolerance, and your energy and wakefulness.
- Protect your blood-brain barrier – keeping toxins out of your brain and preventing negative immune reactions.
- Maintain steady blood sugar levels – which will greatly reduce brain fog and anxiety. Ultrabrain not only has zero sugars but also has the proper amount of protein to help regulate your glucose.
- Regulate your appetite – eating less will reduce inflammation and cellular damage and thus boost your brain health.
- Minimize your caffeine dependence – so you can correct your cognitive function and mood and significantly raise your baseline energy levels.
- Develop metabolic flexibility – helping your body seamlessly switch from burning calories from food to tapping into stored sources of fuel (ie body fat) when needed. Your body’s capacity to easily shift like this is important for maintaining proper brain function and energy levels.
When your brainpower is optimized like this, you'll be better able to:
- Make decisions quickly so you can work more efficiently and get your to-dos done in much less time!
- Sleep soundly through the night so you can bounce out of bed without the need for coffee.
- Handle bad news and stressful situations without anxiety or worry.
- Confidently tackle your problems, big or small.
- Be clear-headed and able to concentrate for long periods of time.
- Recall all the important details of your life with ease (and without the need for post-it notes).
- Complete mentally challenging tasks with plenty of energy to spare. Now is the time to crack open that non-fiction book.
The Ultimate Supplement
Custom formulated with 15 power-packed nutrients, UltraBrain is the ONLY supplement you need to heal your brain and rewire it for lasting clarity, resilience, joy, and energy.
That’s because each of the ingredients are scientifically proven to tackle all types of brain dysfunction.
Take it each day and heal damaged cells, reduce neuroinflammation, and repair faulty communication.
Take it each day and experience renewed mental strength and vitality – that you haven’t felt in years.
Buy UltraBrain Now
1 Month Supply
UltraBrain
$99
Worldwide Shipping (FREE Shipping within the U.S.)*
* For international orders: All shipments are shipped Duties, Customs, & Taxes unpaid. Buyer is responsible for delivery fees.
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$99.00 $74.00
Worldwide Shipping (FREE Shipping within the U.S.)*
* For international orders: All shipments are shipped Duties, Customs, & Taxes unpaid. Buyer is responsible for delivery fees.
3 Month Supply
UltraBrain
$249
Worldwide Shipping (FREE Shipping within the U.S.)*
* For international orders: All shipments are shipped Duties, Customs, & Taxes unpaid. Buyer is responsible for delivery fees.
Worldwide Shipping (FREE Shipping within the U.S.)*
* For international orders: All shipments are shipped Duties, Customs, & Taxes unpaid. Buyer is responsible for delivery fees.
Buy UltraBrain Now
1 Month Supply
UltraBrain
$99 $74.00
Worldwide Shipping (FREE Shipping within the U.S.)*
* For international orders: All shipments are shipped Duties, Customs, & Taxes unpaid. Buyer is responsible for delivery fees.
Subscribe & Save
UltraBrain
$99.00 $64.35
Worldwide Shipping (FREE Shipping within the U.S.)*
* For international orders: All shipments are shipped Duties, Customs, & Taxes unpaid. Buyer is responsible for delivery fees.
3 Month Supply
UltraBrain
$297 $222
Worldwide Shipping (FREE Shipping within the U.S.)*
* For international orders: All shipments are shipped Duties, Customs, & Taxes unpaid. Buyer is responsible for delivery fees.
Worldwide Shipping (FREE Shipping within the U.S.)*
* For international orders: All shipments are shipped Duties, Customs, & Taxes unpaid. Buyer is responsible for delivery fees.
Complete Transparency on the Label
References
All References
- Zhong Z, Han J, Zhang J, Xiao Q, Hu J, Chen L. Pharmacological activities, mechanisms of action, and safety of salidroside in the central nervous system. Drug Des Devel Ther. 2018;12:1479–89.
- Ma G-P, Zheng Q, Xu M-B, Zhou X-L, Lu L, Li Z-X, et al. Rhodiola rosea L. Improves Learning and Memory Function: Preclinical Evidence and Possible Mechanisms. Front Pharmacol. 2018;9:1415.
- Li Y, Pham V, Bui M, Song L, Wu C, Walia A, et al. Rhodiola rosea L.: an herb with anti-stress, anti-aging, and immunostimulating properties for cancer chemoprevention. Curr Pharmacol Rep. 2017;3:384–95.
- Edwards D, Heufelder A, Zimmermann A. Therapeutic effects and safety of Rhodiola rosea extract WS® 1375 in subjects with life-stress symptoms–results of an open-label study. Phytother Res. 2012;26:1220–5.
- Kasper S, Dienel A. Multicenter, open-label, exploratory clinical trial with Rhodiola rosea extract in patients suffering from burnout symptoms. Neuropsychiatr Dis Treat. 2017;13:889–98.
- Lekomtseva Y, Zhukova I, Wacker A. Rhodiola rosea in Subjects with Prolonged or Chronic Fatigue Symptoms: Results of an Open-Label Clinical Trial. Complement Med Res. 2017;24:46–52.
- Spasov AA, Wikman GK, Mandrikov VB, Mironova IA, Neumoin VV. A double-blind, placebo-controlled pilot study of the stimulating and adaptogenic effect of Rhodiola rosea SHR-5 extract on the fatigue of students caused by stress during an examination period with a repeated low-dose regimen. Phytomedicine. 2000;7:85–9.
- Shevtsov VA, Zholus BI, Shervarly VI, Vol’skij VB, Korovin YP, Khristich MP, et al. A randomized trial of two different doses of a SHR-5 Rhodiola rosea extract versus placebo and control of capacity for mental work. Phytomedicine. 2003;10:95–105.
- Olsson EM, von Schéele B, Panossian AG. A randomised, double-blind, placebo-controlled, parallel-group study of the standardised extract shr-5 of the roots of Rhodiola rosea in the treatment of subjects with stress-related fatigue. Planta Med. 2009;75:105–12.
- Cropley M, Banks AP, Boyle J. The Effects of Rhodiola rosea L. Extract on Anxiety, Stress, Cognition and Other Mood Symptoms. Phytother Res. 2015;29:1934–9.
- Darbinyan V, Aslanyan G, Amroyan E, Gabrielyan E, Malmström C, Panossian A. Clinical trial of Rhodiola rosea L. extract SHR-5 in the treatment of mild to moderate depression. Nord J Psychiatry. 2007;61:343–8.
- Bangratz M, Ait Abdellah S, Berlin A, Blondeau C, Guilbot A, Dubourdeaux M, et al. A preliminary assessment of a combination of rhodiola and saffron in the management of mild-moderate depression. Neuropsychiatr Dis Treat. 2018;14:1821–9.
- Sabaratnam V, Kah-Hui W, Naidu M, Rosie David P. Neuronal health – can culinary and medicinal mushrooms help? Afr J Tradit Complement Altern Med. 2013;3:62–8.
- Lai P-L, Naidu M, Sabaratnam V, Wong K-H, David RP, Kuppusamy UR, et al. Neurotrophic properties of the Lion’s mane medicinal mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia. Int J Med Mushrooms. 2013;15:539–54.
- Kawagishi H, Shimada A, Shirai R, Okamoto K, Ojima F, Sakamoto H, et al. Erinacines A, B and C, strong stimulators of nerve growth factor (NGF)-synthesis, from the mycelia of Hericium erinaceum. Tetrahedron Lett. 1994;35:1569–72.
- Kawagishi H, Simada A, Shizuki K, Ojima F, Mori H, Okamoto K, et al. ERINACINE D, A STIMULATOR OF NGF-SYNTHESIS, FROM THE MYCELIA OF HERICIUM ERINACEUM. Heterocycl Commun. 1996;2:4561.
- Mori K, Obara Y, Hirota M, Azumi Y, Kinugasa S, Inatomi S, et al. Nerve growth factor-inducing activity of Hericium erinaceus in 1321N1 human astrocytoma cells. Biol Pharm Bull. 2008;31:1727–32.
- Aloe L, Rocco ML, Balzamino BO, Micera A. Nerve Growth Factor: A Focus on Neuroscience and Therapy. Curr Neuropharmacol. 2015;13:294–303.
- Chiu C-H, Chyau C-C, Chen C-C, Lee L-Y, Chen W-P, Liu J-L, et al. Erinacine A-Enriched Hericium erinaceus Mycelium Produces Antidepressant-Like Effects through Modulating BDNF/PI3K/Akt/GSK-3β Signaling in Mice. Int J Mol Sci [Internet]. 2018;19. Available from: http://dx.doi.org/10.3390/ijms19020341
- Kowiański P, Lietzau G, Czuba E, Waśkow M, Steliga A, Moryś J. BDNF: A Key Factor with Multipotent Impact on Brain Signaling and Synaptic Plasticity. Cell Mol Neurobiol. 2018;38:579–93.
- Yao W, Zhang J-C, Dong C, Zhuang C, Hirota S, Inanaga K, et al. Effects of amycenone on serum levels of tumor necrosis factor-α, interleukin-10, and depression-like behavior in mice after lipopolysaccharide administration. Pharmacol Biochem Behav. 2015;136:7–12.
- Mori K, Inatomi S, Ouchi K, Azumi Y, Tuchida T. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Phytother Res. 2009;23:367–72.
- Vigna L, Morelli F, Agnelli GM, Napolitano F, Ratto D, Occhinegro A, et al. Hericium erinaceus Improves Mood and Sleep Disorders in Patients Affected by Overweight or Obesity: Could Circulating Pro-BDNF and BDNF Be Potential Biomarkers? Evid Based Complement Alternat Med. 2019;2019:7861297.
- Abbiati G, Fossati T, Lachmann G, Bergamaschi M, Castiglioni C. Absorption, tissue distribution and excretion of radiolabelled compounds in rats after administration of [14C]-L-alpha-glycerylphosphorylcholine. Eur J Drug Metab Pharmacokinet. 1993;18:173–80.
- Chin EWM, Goh ELK. Modulating neuronal plasticity with choline. Neural Regeneration Res. 2019;14:1697–8.
- Blusztajn JK, Slack BE, Mellott TJ. Neuroprotective Actions of Dietary Choline. Nutrients [Internet]. 2017;9. Available from: http://dx.doi.org/10.3390/nu9080815
- Parnetti L, Mignini F, Tomassoni D, Traini E, Amenta F. Cholinergic precursors in the treatment of cognitive impairment of vascular origin: ineffective approaches or need for re-evaluation? J Neurol Sci. 2007;257:264–9.
- Galletti P, De Rosa M, Nappi MA, Pontoni G, del Piano L, Salluzzo A, et al. Transport and metabolism of double-labelled CDPcholine in mammalian tissues. Biochem Pharmacol. 1985;34:4121–30.
- Gibellini F, Smith TK. The Kennedy pathway–De novo synthesis of phosphatidylethanolamine and phosphatidylcholine. IUBMB Life. 2010;62:414–28.
- Babb SM, Appelmans KE, Renshaw PF, Wurtman RJ, Cohen BM. Differential effect of CDP-choline on brain cytosolic choline levels in younger and older subjects as measured by proton magnetic resonance spectroscopy. Psychopharmacology . 1996;127:88–94.
- Babb SM, Wald LL, Cohen BM, Villafuerte RA, Gruber SA, Yurgelun-Todd DA, et al. Chronic citicoline increases phosphodiesters in the brains of healthy older subjects: an in vivo phosphorus magnetic resonance spectroscopy study. Psychopharmacology . 2002;161:248–54.
- Fioravanti M, Yanagi M. Cytidinediphosphocholine (CDP-choline) for cognitive and behavioural disturbances associated with chronic cerebral disorders in the elderly. Cochrane Database Syst Rev. 2005;CD000269.
- Castagna A, Cotroneo AM, Ruotolo G, Gareri P. The CITIRIVAD Study: CITIcoline plus RIVAstigmine in Elderly Patients Affected with Dementia Study. Clin Drug Investig. 2016;36:1059–65.
- Gareri P, Castagna A, Cotroneo AM, Putignano D, Conforti R, Santamaria F, et al. The Citicholinage Study: Citicoline Plus Cholinesterase Inhibitors in Aged Patients Affected with Alzheimer’s Disease Study. J Alzheimers Dis. 2017;56:557–65.
- McGlade E, Agoston AM, DiMuzio J, Kizaki M, Nakazaki E, Kamiya T, et al. The Effect of Citicoline Supplementation on Motor Speed and Attention in Adolescent Males. J Atten Disord. 2019;23:121–34.
- McGlade E, Locatelli A, Hardy J, Kamiya T, Morita M, Morishita K, et al. Improved Attentional Performance Following Citicoline Administration in Healthy Adult Women. FNS. 2012;03:769–73.
- Abdul Manap AS, Vijayabalan S, Madhavan P, Chia YY, Arya A, Wong EH, et al. Bacopa monnieri, a Neuroprotective Lead in Alzheimer Disease: A Review on Its Properties, Mechanisms of Action, and Preclinical and Clinical Studies. Drug Target Insights. 2019;13:1177392819866412.
- Dubey T, Chinnathambi S. Brahmi (Bacopa monnieri): An ayurvedic herb against the Alzheimer’s disease. Arch Biochem Biophys. 2019;676:108153.
- Kwon HJ, Jung HY, Hahn KR, Kim W, Kim JW, Yoo DY, et al. extract improves novel object recognition, cell proliferation, neuroblast differentiation, brain-derived neurotrophic factor, and phosphorylation of cAMP response element-binding protein in the dentate gyrus. Lab Anim Res. 2018;34:239–47.
- Chaudhari KS, Tiwari NR, Tiwari RR, Sharma RS. Neurocognitive Effect of Nootropic Drug () in Alzheimer’s Disease. Ann Neurosci. 2017;24:111–22.
- Aguiar S, Borowski T. Neuropharmacological review of the nootropic herb Bacopa monnieri. Rejuvenation Res. 2013;16:313–26.
- Peth-Nui T, Wattanathorn J, Muchimapura S, Tong-Un T, Piyavhatkul N, Rangseekajee P, et al. Effects of 12-Week Bacopa monnieri Consumption on Attention, Cognitive Processing, Working Memory, and Functions of Both Cholinergic and Monoaminergic Systems in Healthy Elderly Volunteers. Evid Based Complement Alternat Med. 2012;2012:606424.
- Calabrese C, Gregory WL, Leo M, Kraemer D, Bone K, Oken B. Effects of a standardized Bacopa monnieri extract on cognitive performance, anxiety, and depression in the elderly: a randomized, double-blind, placebo-controlled trial. J Altern Complement Med. 2008;14:707–13.
- Morgan A, Stevens J. Does Bacopa monnieri improve memory performance in older persons? Results of a randomized, placebo-controlled, double-blind trial. J Altern Complement Med. 2010;16:753–9.
- Stough C, Lloyd J, Clarke J, Downey LA, Hutchison CW, Rodgers T, et al. The chronic effects of an extract of Bacopa monniera (Brahmi) on cognitive function in healthy human subjects. Psychopharmacology . 2001;156:481–4.
- Stough C, Downey LA, Lloyd J, Silber B, Redman S, Hutchison C, et al. Examining the nootropic effects of a special extract of Bacopa monniera on human cognitive functioning: 90 day double-blind placebo-controlled randomized trial. Phytother Res. 2008;22:1629–34.
- Kumar N, Abichandani LG, Thawani V, Gharpure KJ, Naidu MUR, Venkat Ramana G. Efficacy of Standardized Extract of Bacopa monnieri (Bacognize®) on Cognitive Functions of Medical Students: A Six-Week, Randomized Placebo-Controlled Trial. Evid Based Complement Alternat Med. 2016;2016:4103423.
- Goswami S, Kumar N, Thawani V, Tiwari M, Thawani M, Others. Effect of Bacopa monnieri on cognitive functions in Alzheimer’s disease patients. International Journal of Collaborative Research on Internal Medicine & Public Health. Longdom Publishing SL; 2011;3:0–0.
- Singh SK, Srivastav S, Castellani RJ, Plascencia-Villa G, Perry G. Neuroprotective and Antioxidant Effect of Ginkgo biloba Extract Against AD and Other Neurological Disorders. Neurotherapeutics. 2019;16:666–74.
- Yuan Q, Wang C-W, Shi J, Lin Z-X. Effects of Ginkgo biloba on dementia: An overview of systematic reviews. J Ethnopharmacol. 2017;195:1–9.
- Liu H, Ye M, Guo H. An Updated Review of Randomized Clinical Trials Testing the Improvement of Cognitive Function of Ginkgo biloba Extract in Healthy People and Alzheimer’s Patients. Front Pharmacol. 2019;10:1688.
- Mullen W, Nemzer B, Ou B, Stalmach A, Hunter J, Clifford MN, et al. The antioxidant and chlorogenic acid profiles of whole coffee fruits are influenced by the extraction procedures. J Agric Food Chem. 2011;59:3754–62.
- Duangjai A, Suphrom N, Wungrath J, Ontawong A, Nuengchamnong N, Yosboonruang A. Comparison of antioxidant, antimicrobial activities and chemical profiles of three coffee (Coffea arabica L.) pulp aqueous extracts. Integr Med Res. 2016;5:324–31.
- Reyes-Izquierdo T, Nemzer B, Shu C, Huynh L, Argumedo R, Keller R, et al. Modulatory effect of coffee fruit extract on plasma levels of brain-derived neurotrophic factor in healthy subjects. Br J Nutr. 2013;110:420–5.
- Reyes-Izquierdo T, Argumedo R, Shu C, Nemzer B, Pietrzkowski Z. Stimulatory Effect of Whole Coffee Fruit Concentrate Powder on Plasma Levels of Total and Exosomal Brain-Derived Neurotrophic Factor in Healthy Subjects: An Acute Within-Subject Clinical Study. FNS. 2013;04:984–90.
- Calabrese F, Rossetti AC, Racagni G, Gass P, Riva MA, Molteni R. Brain-derived neurotrophic factor: a bridge between inflammation and neuroplasticity. Front Cell Neurosci. 2014;8:430.
- Rossi C, Angelucci A, Costantin L, Braschi C, Mazzantini M, Babbini F, et al. Brain-derived neurotrophic factor (BDNF) is required for the enhancement of hippocampal neurogenesis following environmental enrichment. Eur J Neurosci. 2006;24:1850–6.
- Cohen-Cory S, Kidane AH, Shirkey NJ, Marshak S. Brain-derived neurotrophic factor and the development of structural neuronal connectivity. Dev Neurobiol. 2010;70:271–88.
- Bekinschtein P, Cammarota M, Katche C, Slipczuk L, Rossato JI, Goldin A, et al. BDNF is essential to promote persistence of long-term memory storage. Proc Natl Acad Sci U S A. 2008;105:2711–6.
- Chen S-D, Wu C-L, Hwang W-C, Yang D-I. More Insight into BDNF against Neurodegeneration: Anti-Apoptosis, Anti-Oxidation, and Suppression of Autophagy. Int J Mol Sci [Internet]. 2017;18. Available from: http://dx.doi.org/10.3390/ijms18030545
- Dos Santos TC, Gomes TM, Pinto BAS, Camara AL, Paes AM de A. Naturally Occurring Acetylcholinesterase Inhibitors and Their Potential Use for Alzheimer’s Disease Therapy. Front Pharmacol. 2018;9:1192.
- Yang G, Wang Y, Tian J, Liu J-P. Huperzine A for Alzheimer’s disease: a systematic review and meta-analysis of randomized clinical trials. PLoS One. 2013;8:e74916.
- Xing S-H, Zhu C-X, Zhang R, An L. Huperzine a in the treatment of Alzheimer’s disease and vascular dementia: a meta-analysis. Evid Based Complement Alternat Med. 2014;2014:363985.
- Zheng W, Xiang Y-Q, Ungvari GS, Chiu FKH, H Ng C, Wang Y, et al. Huperzine A for treatment of cognitive impairment in major depressive disorder: a systematic review of randomized controlled trials. Shanghai Arch Psychiatry. 2016;28:64–71.
- Nicassio L, Fracasso F, Sirago G, Musicco C, Picca A, Marzetti E, et al. Dietary supplementation with acetyl-l-carnitine counteracts age-related alterations of mitochondrial biogenesis, dynamics and antioxidant defenses in brain of old rats. Exp Gerontol. 2017;98:99–109.
- Smeland OB, Meisingset TW, Borges K, Sonnewald U. Chronic acetyl-L-carnitine alters brain energy metabolism and increases noradrenaline and serotonin content in healthy mice. Neurochem Int. 2012;61:100–7.
- Kobayashi S, Iwamoto M, Kon K, Waki H, Ando S, Tanaka Y. Acetyl-L-carnitine improves aged brain function. Geriatr Gerontol Int. 2010;10 Suppl 1:S99–106.
- Aliev G, Liu J, Shenk JC, Fischbach K, Pacheco GJ, Chen SG, et al. Neuronal mitochondrial amelioration by feeding acetyl-L-carnitine and lipoic acid to aged rats. J Cell Mol Med. 2009;13:320–33.
- Parnetti L, Gaiti A, Mecocci P, Cadini D, Senin U. Pharmacokinetics of IV and oral acetyl-L-carnitine in a multiple dose regimen in patients with senile dementia of Alzheimer type. Eur J Clin Pharmacol. 1992;42:89–93.
- Cristofano A, Sapere N, La Marca G, Angiolillo A, Vitale M, Corbi G, et al. Serum Levels of Acyl-Carnitines along the Continuum from Normal to Alzheimer’s Dementia. PLoS One. 2016;11:e0155694.
- Montgomery SA, Thal LJ, Amrein R. Meta-analysis of double blind randomized controlled clinical trials of acetyl-L-carnitine versus placebo in the treatment of mild cognitive impairment and mild Alzheimer’s disease. Int Clin Psychopharmacol. 2003;18:61–71.
- Malaguarnera M, Gargante MP, Cristaldi E, Colonna V, Messano M, Koverech A, et al. Acetyl L-carnitine (ALC) treatment in elderly patients with fatigue. Arch Gerontol Geriatr. 2008;46:181–90.
- Veronese N, Stubbs B, Solmi M, Ajnakina O, Carvalho AF, Maggi S. Acetyl-L-Carnitine Supplementation and the Treatment of Depressive Symptoms: A Systematic Review and Meta-Analysis. Psychosom Med. 2018;80:154–9.
- Hausenblas HA, Saha D, Dubyak PJ, Anton SD. Saffron (Crocus sativus L.) and major depressive disorder: a meta-analysis of randomized clinical trials. J Integr Med. 2013;11:377–83.
- Yang X, Chen X, Fu Y, Luo Q, Du L, Qiu H, et al. Comparative efficacy and safety of Crocus sativus L. for treating mild to moderate major depressive disorder in adults: a meta-analysis of randomized controlled trials. Neuropsychiatr Dis Treat. 2018;14:1297–305.
- Khaksarian M, Behzadifar M, Behzadifar M, Alipour M, Jahanpanah F, Re TS, et al. The efficacy of Crocus sativus (Saffron) versus placebo and Fluoxetine in treating depression: a systematic review and meta-analysis. Psychol Res Behav Manag. 2019;12:297–305.
- Esalatmanesh S, Biuseh M, Noorbala AA, Mostafavi S-A, Rezaei F, Mesgarpour B, et al. Comparison of Saffron and Fluvoxamine in the Treatment of Mild to Moderate Obsessive-Compulsive Disorder: A Double Blind Randomized Clinical Trial. Iran J Psychiatry. 2017;12:154–62.
- Akhondzadeh S, Sabet MS, Harirchian MH, Togha M, Cheraghmakani H, Razeghi S, et al. Saffron in the treatment of patients with mild to moderate Alzheimer’s disease: a 16-week, randomized and placebo-controlled trial. J Clin Pharm Ther. 2010;35:581–8.
- Akhondzadeh S, Shafiee Sabet M, Harirchian MH, Togha M, Cheraghmakani H, Razeghi S, et al. A 22-week, multicenter, randomized, double-blind controlled trial of Crocus sativus in the treatment of mild-to-moderate Alzheimer’s disease. Psychopharmacology . 2010;207:637–43.
- Kakuda T. Neuroprotective effects of theanine and its preventive effects on cognitive dysfunction. Pharmacol Res. 2011;64:162–8.
- Yamada T, Terashima T, Okubo T, Juneja LR, Yokogoshi H. Effects of theanine, r-glutamylethylamide, on neurotransmitter release and its relationship with glutamic acid neurotransmission. Nutr Neurosci. 2005;8:219–26.
- Kobayashi K, Nagato Y, Aoi N, Juneja LR, Kim M, Yamamoto T, et al. Effects of L-theanine on the release of alpha-brain waves in human volunteers. Journal of the Agricultural Chemical Society of Japan (Japan) [Internet]. 1998; Available from: http://agris.fao.org/agris-search/search.do?recordID=JP1998003883
- Juneja LR, Chu D-C, Okubo T, Nagato Y, Yokogoshi H. L-theanine—a unique amino acid of green tea and its relaxation effect in humans. Trends Food Sci Technol. 1999;10:199–204.
- Nobre AC, Rao A, Owen GN. L-theanine, a natural constituent in tea, and its effect on mental state. Asia Pac J Clin Nutr. 2008;17 Suppl 1:167–8.
- Gomez-Ramirez M, Kelly SP, Montesi JL, Foxe JJ. The effects of L-theanine on alpha-band oscillatory brain activity during a visuo-spatial attention task. Brain Topogr. 2009;22:44–51.
- Higashiyama A, Htay HH, Ozeki M, Juneja LR, Kapoor MP. Effects of l-theanine on attention and reaction time response. J Funct Foods. 2011;3:171–8.
- Dietz C, Dekker M. Effect of Green Tea Phytochemicals on Mood and Cognition. Curr Pharm Des. 2017;23:2876–905.
- Williams JL, Everett JM, D’Cunha NM, Sergi D, Georgousopoulou EN, Keegan RJ, et al. The Effects of Green Tea Amino Acid L-Theanine Consumption on the Ability to Manage Stress and Anxiety Levels: a Systematic Review. Plant Foods Hum Nutr. 2020;75:12–23.
- Uzbay TI. The pharmacological importance of agmatine in the brain. Neurosci Biobehav Rev. 2012;36:502–19.
- Shopsin B. The clinical antidepressant effect of exogenous agmatine is not reversed by parachlorophenylalanine: a pilot study. Acta Neuropsychiatr. 2013;25:113–8.
- Keynan O, Mirovsky Y, Dekel S, Gilad VH, Gilad GM. Safety and Efficacy of Dietary Agmatine Sulfate in Lumbar Disc-associated Radiculopathy. An Open-label, Dose-escalating Study Followed by a Randomized, Double-blind, Placebo-controlled Trial. Pain Med. 2010;11:356–68.
- May BH, Lu C, Lu Y, Zhang AL, Xue CCL. Chinese herbs for memory disorders: a review and systematic analysis of classical herbal literature. J Acupunct Meridian Stud. 2013;6:2–11.
- Park CH, Choi SH, Koo J-W, Seo J-H, Kim H-S, Jeong S-J, et al. Novel cognitive improving and neuroprotective activities of Polygala tenuifolia Willdenow extract, BT-11. J Neurosci Res. 2002;70:484–92.
- Li Z, Liu Y, Wang L, Liu X, Chang Q, Guo Z, et al. Memory-Enhancing Effects of the Crude Extract of Polygala tenuifolia on Aged Mice. Evid Based Complement Alternat Med. 2014;2014:392324.
- Xue W, Hu J-F, Yuan Y-H, Sun J-D, Li B-Y, Zhang D-M, et al. Polygalasaponin XXXII from Polygala tenuifolia root improves hippocampal-dependent learning and memory. Acta Pharmacol Sin. 2009;30:1211–9.
- Park H-J, Lee K, Heo H, Lee M, Kim JW, Whang WW, et al. Effects of Polygala tenuifolia root extract on proliferation of neural stem cells in the hippocampal CA1 region. Phytother Res. 2008;22:1324–9.
- Lee J-Y, Kim KY, Shin KY, Won BY, Jung HY, Suh Y-H. Effects of BT-11 on memory in healthy humans. Neurosci Lett. 2009;454:111–4.
- Shin KY, Lee J-Y, Won BY, Jung HY, Chang K-A, Koppula S, et al. BT-11 is effective for enhancing cognitive functions in the elderly humans. Neurosci Lett. 2009;465:157–9.
- Fernstrom JD, Fernstrom MH. Tyrosine, phenylalanine, and catecholamine synthesis and function in the brain. J Nutr. 2007;137:1539S – 1547S; discussion 1548S.
- Goldstein DS. Catecholamines 101. Clin Auton Res. 2010;20:331–52.
- Lehnert H, Reinstein DK, Strowbridge BW, Wurtman RJ. Neurochemical and behavioral consequences of acute, uncontrollable stress: effects of dietary tyrosine. Brain Res. 1984;303:215–23.
- Hase A, Jung SE, aan het Rot M. Behavioral and cognitive effects of tyrosine intake in healthy human adults. Pharmacol Biochem Behav. 2015;133:1–6.
- Jongkees BJ, Hommel B, Kühn S, Colzato LS. Effect of tyrosine supplementation on clinical and healthy populations under stress or cognitive demands–A review. J Psychiatr Res. 2015;70:50–7.
- Neri DF, Wiegmann D, Stanny RR, Shappell SA, McCardie A, McKay DL. The effects of tyrosine on cognitive performance during extended wakefulness. Aviat Space Environ Med. 1995;66:313–9.
- Deijen JB, Wientjes CJ, Vullinghs HF, Cloin PA, Langefeld JJ. Tyrosine improves cognitive performance and reduces blood pressure in cadets after one week of a combat training course. Brain Res Bull. 1999;48:203–9.
- Mahoney CR, Castellani J, Kramer FM, Young A, Lieberman HR. Tyrosine supplementation mitigates working memory decrements during cold exposure. Physiol Behav. 2007;92:575–82.
- Swaminathan R. Magnesium metabolism and its disorders. Clin Biochem Rev. 2003;24:47–66.
- Clerc P, Young CA, Bordt EA, Grigore AM, Fiskum G, Polster BM. Magnesium sulfate protects against the bioenergetic consequences of chronic glutamate receptor stimulation. PLoS One. 2013;8:e79982.
- Lambuk L, Jafri AJA, Arfuzir NNN, Iezhitsa I, Agarwal R, Rozali KNB, et al. Neuroprotective Effect of Magnesium Acetyltaurate Against NMDA-Induced Excitotoxicity in Rat Retina. Neurotox Res. 2017;31:31–45.
- Kirkland AE, Sarlo GL, Holton KF. The Role of Magnesium in Neurological Disorders. Nutrients [Internet]. 2018;10. Available from: http://dx.doi.org/10.3390/nu10060730
- Uysal N, Kizildag S, Yuce Z, Guvendi G, Kandis S, Koc B, et al. Timeline (Bioavailability) of Magnesium Compounds in Hours: Which Magnesium Compound Works Best? Biol Trace Elem Res. 2019;187:128–36.
